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Review Article: A Review of Chronic Inhalation Studies with Mainstream Cigarette Smoke, in Hamsters, Dogs, and Nonhuman Primates

Lorillard Tobacco Company, Greensboro, North Carolina 27420, USA, ccoggins{at}lortobco.com

This paper is the continuation of previously published work, a review limited to studies on rats and mice. This paper makes an identical evaluation as before, but, restricting the species being evaluated to representative studies of smoke-exposed hamsters, dogs (both by tracheostomy and by direct inhalation), and nonhuma n primates. As was seen previously, no statistically significant increase in the incidence of malignant tumors of the respiratory tract was found in any of the 3 species, even though very long exposures and high doses of smoke were used. All 5 of the species of laboratory animals commonly used to evaluate carcinogenic potential produce results with mainstream cigarette smoke that are at variance with the epidemiological evidence in smokers.

Key Words: Cigarette smoke • dog • hamster • inhalation toxicology • nonhuman primate • respiratory tract.

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