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Review Article: Compendium of Chemical Carcinogens by Target Organ: Results of Chronic Bioassays in Rats, Mice, Hamsters, Dogs, and Monkeys

Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720-3202, lois{at}potency.berkeley.edu, Life Sciences Division, Mail Stop: 946, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720

Neela B. Manley

Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720-3202

Thomas H. Slone

Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720-3202

Jerrold M. Ward

Veterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201

A compendium of carcinogenesi s bioassay results organized by target organ is presented for 738 chemicals that are carcinogeni c in chronic-exposure, long-term bioassays in at least 1 species. This compendium is based primarily on experiments in rats or mice; results in hamsters, monkeys, and dogs are also reported. The compendium can be used to identify chemicals that induce tumors at particular sites and to determine whether target sites are the same for chemicals positive in more than 1 species. The source of information is the Carcinogenic Potency Database (CPDB), which includes results of 6073 experiments on 1458 chemicals (positive or negative for carcinogenicity) that have been reported in Technical Reports of the National Cancer Institute/National Toxicology Program or in papers in the general published literature. The published CPDB includes detailed analyses of each test and citations. The CPDB is publicly available in several formats (http://potency.berkeley.edu). Chemical carcinogens are reported for 35 different target organs in rats or mice. Target organs in humans are also summarized for 82 agents that have been evaluated as human carcinogens at a particular target site by the International Agency for Research on Cancer (IARC). Comparisons are provided of target organs for mutagens versus nonmutagens and rats versus mice.

Key Words: Human carcinogen • tumor site • animal cancer test • Carcinogenic Potency Database • species comparisons • mutagenicity • monkeys.

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