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Toxicologic Pathology
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Recovery of Injured Adrenal Medulla by Differentiation of Pre-Existing Undifferentiated Chromaffi n Cells

Cleo Chen-Pan

Department of Veterinary Anatomy, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

In Jen Pan

Laboratory of Veterinary Epizootiology, College of Bioresource Sciences, Nihon University, Fujisawa-shi, Kanagawa, Japan, ijpan{at}brs.nihou-u.ac.jp

Yuzuru Yamamoto

Research Institute for Animal Science in Biochemistry and Toxicology, Sagamihara-shi, Kanagawa, Japan

Hans Hc Chen

National Laboratory Animal Breeding and Research Center, National Science Council, Nankang, Taipei, Taiwan (ROC)

Yoshiro Hayashi

Department of Veterinary Anatomy, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

We described previous that the adrenal medulla recovers rapidly from the injuries due to salinomycin. In the present study we found the recovery to be apparently due to differentiation of pre-existing, primitive undifferentiated, chromaffi n cells, rather than mitosis, as evidenced by lack of incorporation of 5-bromo-2-deoxyuridin e in the differentiating and/or differentiated chromaffi n cells. Electron-dense, striated fi brils observed within the necrotic cells and in the extracellular space were presumed to be intermediate degradation products. Schwann cells actively functioned as phagocytes in this study, and seemed to indirectly stimulate the differentiation of undifferentiated chromaffi n cells.

Key Words: Adrenal medulla • adrenal cortex • chromaffi n cells • pheochromoblast • Schwann cell • salinomycin.

Toxicologic Pathology, Vol. 30, No. 2, 165-172 (2002)
DOI: 10.1080/019262302753559498
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