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DOI: 10.1080/019262302753559588 Species Differences in the Distribution of Drug-Metabolizing Enzymes in the PancreasUNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, Department of Surgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany
UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, Department of Surgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany
UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, Department of Visceral and Transplantation Surgery, Insel Hospital, Bern, Switzerland
UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, Department of Visceral and Transplantation Surgery, Insel Hospital, Bern, Switzerland
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska
UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, ppour{at}unmc.edu., Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska
We investigated the cellular expression of 9 cytochrome P450-isozymes (CYP1A1, CYP1A2, CYP2B6, CYP2C8,9,19, CYP2D1, CYP2E1, CYP3A1, CYP3A2, CYP3A4) and 3 glutathione S-transferase-isozymes (GST-
Key Words: Drug-metabolizing enzymes cytochrome P450 glutathione S-transferase laboratory animals.
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, GST-
, GST-µ ) in the pancreas of hamsters, mice, rats, rabbits, pigs, dogs and monkeys, and in comparison with the human pancreas. A wide variation was found in the cellular localization of these enzymes between the 8 species. Most enzymes were expressed in the pancreas of the hamster, mouse, monkey and human, whereas rats, pigs, rabbits and dogs were lacking several isozymes. However, in all of the species the islet cells expressed more enzymes than ductal and acinar cells. An exclusive expression of enzymes in the islet cells was found in the hamster (CYP2E1), mouse (CYP1A1, CYP1A2, GST-