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Toxicologic Pathology
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*MALONALDEHYDE
*METHYL METHACRYLATE
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The Effects of Methyl Methacrylate on Nasal Cavity, Lung, and Antioxidant System (An Experimental Inhalation Study)

Ozlem Aydin

Department of Pathology, Mersin University Medical School, Mersin-Icel, Turkey, ozlemaydin66{at}hotmail.com

Gulen Attila

Department of Biochemistry, Cukurova University Medical School, Adana, Turkey

Arife Dogan

Department of Prosthetic Dentistry, Gazi University School of Dentistry, Ankara, Turkey

Mehmet Volkan Aydin

Department of Neurosurgery, Baskent University Medical School, Adana, Turkey

Necmiye Canacankatan

Department of Biochemistry, Cukurova University Medical School, Adana, Turkey

Arzu Kanik

Department of Biostatistics, Mersin University Medical School, Mersin-Icel, Turkey

Methyl methacrylate (MMA) is a monomer, commonly used in neurosurgery, orthopedic surgery, and in dental clinics. The adverse effects of this monomer are well described in the literature. This study was designed to evaluate the effects of MMA on nasal cavity, lung, and antioxidant status. For this purpose, two experimental groups of rats were exposed to MMA (at 1000 ppm, 6 h/day, 5 days/week for 4 weeks) by inhalation under poor (group A, n = 12) and normal ventilation (group B, n = 11) conditions. A control group (group C, n = 10) received normal air. Degeneration of olfactory epithelium, bronchopneumonia , interstitial pneumonia, hemorrhage, atelectasis, edema, emphysema, and bronchial epithelial hyperplasia were observed in groups A and B. Emphysema was the most common lesion. Bronchopneumoni a with abscesses was only observed in group A. Glutathione levels were signifi cantly decreased and malondialdehyde levels were signifi cantly increased in group A. No signifi cant difference was observed in superoxide dismutase levels between the groups. The data presented indicate that before using MMA, adequate protection systems should be in place to prevent occupationally related MMA respiratory-tract injuries.

Key Words: Antioxidant system • inhalation • lungs • methyl methacrylate • nasal cavity • rats.

Toxicologic Pathology, Vol. 30, No. 3, 350-356 (2002)
DOI: 10.1080/01926230252929927
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