This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moyer, C. F. Articles by Nyska, A. Search for Related Content PubMed PubMed Citation Articles by Moyer, C. F. Articles by Nyska, A. Social Bookmarking                   What's this?

Systemic Vascular Disease in Male B6C3F1 Mice Exposed to Particulate Matter by Inhalation: Studies Conducted by the National Toxicology Program

Pathology Associates, Raleigh, North Carolina 27606, USA

Urmila P. Kodavanti

Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA

Joseph K. Haseman

Biostatics Branch, National Institute of Environmental Health, Research Branch, Research Triangle Park, North Carolina 27709, USA

L. Costa

Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA

Abraham Nyska

Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, nyska{at}niehs.nih.gov.

Epidemiological studies suggest an association between ambient particulate matter and cardiopulmonary diseases in humans. The mechanisms underlying these health effects are poorly understood. To better understand the potential relationship between particulate-matter-induced inflammation and vascular disease, a 2-phase retrospective study was conducted. Phase one included the review of heart, lung, and kidney tissues from high-dose and control male B6C3F1 mice exposed by inhalation to 9 particulate compounds for a 2-year period. The results showed that high-dose males developed significantly increased incidences of coronary and renal arteritis over controls in 2 of the 9 studies (indium phosphide and cobalt sulfate heptahydrate), while marginal increases in arteritis incidence was detected in 2 additional studies (vanadium pentoxide and gallium arsenide). In contrast, arteritis of the muscular arteries of the lung was not observed. Morphological features of arteritis in these studies included an influx of mixed inflammatory cells including neutrophils, lymphocytes, and macrophages. Partial and complete effacement of the normal vascular wall architecture, often with extension of the inflammatory process into the periarterial connective tissue, was observed. Phase 2 evaluated the heart, lung, kidney, and mesentery of male and female B6C3F1 mice from the 90-day studies of the 4 compounds demonstrating arteritis after a 2-year period. The results showed arteritis did not develop in the 90-day studies, suggesting that long-term chronic exposure to lower-dose metallic particulate matter may be necessary to induce or exacerbate arteritis.

Key Words: Air pollution • indium phosphide • cobalt sulfate heptahydrate • mouse • heart • arteritis.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. Rehm, R. A. Thomas, K. S. Smith, R. C. Mirabile, T. L. Gales, S. L. Eustis, and R. W. Boyce Novel Vascular Lesions in Mice Given a Non-Peptide Vitronectin Receptor Antagonist Toxicol Pathol, December 1, 2007; 35(7): 958 - 971. [Abstract] [Full Text] [PDF]