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Toxicologic Pathology
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"Have You Seen This?" Peliosis Hepatis

Richard Edwards

MRC Toxicology Unit, Hodgkin Building, University of Leicester, Leicester LE1 9HN, United Kingdom, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

Tina Colombo

MRC Toxicology Unit, Hodgkin Building, University of Leicester, Leicester LE1 9HN, United Kingdom, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

Peter Greaves

MRC Toxicology Unit, Hodgkin Building, University of Leicester, Leicester LE1 9HN, United Kingdom, pg29{at}le.ac.uk, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

Peliosis hepatis, characterized by the presence of blood-filled spaces within hepatic parenchyma, developed in C57B1 mice implanted subcutaneously with melanoma cells 23 days previously. The peliosis was associated with dilated hepatic sinusoids that were lined by prominent, proliferating endothelial cells. The development of peliosis hepatis was completely abrogated when melanoma growth was inhibited by administration of dexamethasone. These features support the concept that peliosis hepatis can be induced by a circulating tumor-derived endothelial growth factor such as vascular endothelial growth factor.

Key Words: Liver • peliosis • mouse • dexamethasone • melanoma • immunocytochemistry.

Toxicologic Pathology, Vol. 30, No. 4, 521-523 (2002)
DOI: 10.1080/01926230290105686
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