Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 30, No. 5, 552-558 (2002)
DOI: 10.1080/01926230290105767

Protective Effect of Topical Iodine Preparations Upon Heat-Induced and Hydrofluoric Acid-Induced Skin Lesions

Uri Wormser

Faculty of Sciences, The Hebrew University, Givat Ram, 91904, Jerusalem, Israel, wormser{at}cc.huji.ac.il

Amnon Sintov

Institutesfor Applied Research, Ben Gurion University of the Negev, Beer-Sheva, Israel

Berta Brodsky

Faculty of Sciences, The Hebrew University, Givat Ram, 91904, Jerusalem, Israel

Yona Amitai

Mother Child and Adolescent Health Department, Ministry of Health, Jerusalem, Israel

Abraham Nyska

Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

In this study, the protectiveprophylacti c and post-exposure effects of novel topical iodine preparations were demonstrated uponheat- and hydrofluoric acid-induced skin lesions in the haired guinea pig. Prophylactic treatment of thermal burns with a liquid iodine preparation resulted in statistically significant reductions of 39% and 30%, respectively, in acute inflammation and hemorrhage-microscopi c dermal parameters indicative of acute tissue damage. A clear trend of iodine-induced reduction in dermal necrosis occurred, and the epidermal healing markers, acanthosis and hyperkeratosis, were increased. Postexposure treatment of thermal burns with an iodine ointment preparation immediately after occurrence also conferred significant therapeutic reduction in parameters of tissue damage such as epidermal ulceration (87%), acute inflammation (58%), and hemorrhage (30%). Gross pathological evaluation showed that prophylactic and postexposure treatments with the liquid iodine preparation significantly reduced the heat-induced ulceration area by 97% and 65%, respectively. In addition, immediate treatment with an ointment iodine formulation significantly decreased the ulceration area by 98%; its tetraglycol vehicle also had a beneficial effect. Postexposure treatment with the iodine ointment proved efficacious upon hydrofluoric acid-induced skin burns. We observed statistically significant reductions of 76% and 68% in ulceration areas at intervals of 5 and 10 minutes between exposure and treatment, whereas a weaker effect was observed at a longer time interval of 15 minutes. Our findings suggest the therapeutic usage of these newly developed iodine preparations for thermally induced and hydrofluoric acid-induced skin burns.

Key Words: Chemical exposure • dermal toxicity.


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