Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Newbold, R. R.
Right arrow Articles by Dixon, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Newbold, R. R.
Right arrow Articles by Dixon, D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Characterization of Uterine Leiomyomas in CD-1 Mice Following Developmental Exposure to Diethylstilbestrol (DES)

Retha R. Newbold

Developmental Endocrinology Section, Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Alicia B. Moore

Comparative Pathobiology Group, Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Darlene Dixon

Comparative Pathobiology Group, Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, dixon{at}niehs.nih.gov

Experimental animal and clinical studies have well established the association of prenatal exposure to diethylstilbestrol (DES) and the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia. Overwhelmingly, the focus has been on DES-induced epithelial lesions, particularly vaginal adenosis and adenocarcinoma; however, uterine smooth muscle cells are also recognized as cellular targets of DES. This descriptive report characterizes uterine leiomyoma s that occur in outbred CD-1 mice following exposure to DES prenatally on days 9 to 16 of gestation or on neonatal days 1 to 5. These DES-induced uterine leiomyomas have typical histomorphologic, and some immunohistochemica l characteristics of spontaneously occurring uterine smooth muscle tumors of B6C3F1 mice previously described in our laboratory, and they are also similar to uterine leiomyomas (fibroids) commonly observed in premenopausal women.

Key Words: Diethylstilbestrol • DES • leiomyomas • uterus • mice • growth factors.

Toxicologic Pathology, Vol. 30, No. 5, 611-616 (2002)
DOI: 10.1080/01926230290105839
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
J. S. Crabtree, S. A. Jelinsky, H. A. Harris, S. E. Choe, M. M. Cotreau, M. L. Kimberland, E. Wilson, K. A. Saraf, W. Liu, A. S. McCampbell, et al.
Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway
Cancer Res., August 1, 2009; 69(15): 6171 - 6178.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
E. Diamanti-Kandarakis, J.-P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins, A. M. Soto, R. T. Zoeller, and A. C. Gore
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Endocr. Rev., June 1, 2009; 30(4): 293 - 342.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. N. Nierth-Simpson, M. M. Martin, T.-C. Chiang, L. I. Melnik, L. V. Rhodes, S. E. Muir, M. E. Burow, and J. A. McLachlan
Human Uterine Smooth Muscle and Leiomyoma Cells Differ in Their Rapid 17{beta}-Estradiol Signaling: Implications for Proliferation
Endocrinology, May 1, 2009; 150(5): 2436 - 2445.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
K.L. Greathouse, J.D. Cook, K. Lin, B.J. Davis, T.D. Berry, T.G. Bredfeldt, and C.L. Walker
Identification of Uterine Leiomyoma Genes Developmentally Reprogrammed by Neonatal Exposure to Diethylstilbestrol
Reproductive Sciences, October 1, 2008; 15(8): 765 - 778.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
X. Di, L. Yu, A.B. Moore, L. Castro, X. Zheng, T. Hermon, and D. Dixon
A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells
Hum. Reprod., August 1, 2008; 23(8): 1873 - 1883.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
N. J. Barlow, B. S. Mcintyre, and P. M.D. Foster
Male Reproductive Tract Lesions at 6, 12, and 18 Months of Age Following in Utero Exposure to Di(n-butyl) Phthalate
Toxicol Pathol, January 1, 2004; 32(1): 79 - 90.
[Abstract] [PDF]