Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 30, No. 6, 723-734 (2002)
DOI: 10.1080/01926230290166814

Methylmercury Poisoning in Common Marmosets—MRI Findings and Peripheral Nerve Lesions

Komyo Eto

National Institute for Minamata Disease, Minamata City, Kumamoto, Japan, kometo{at}nimd.go.jp

Akira Yasutake

National Institute for Minamata Disease, Minamata City, Kumamoto, Japan

Yukunori Korogi

Department of Radiology, Kumamoto University School of Medicine, Kumamoto, Japan

Michio Akima

Department of Pathology, Toho University School of Medicine, Tokyo, Japan

Toshie Shimozeki

Department of Pathology, Toho University School of Medicine, Tokyo, Japan

Hidehiro Tokunaga

Department of Surgical Pathology, Kumamoto University School of Medicine, Kumamoto, Japan

Takashi Kuwana

National Institute for Minamata Disease, Minamata City, Kumamoto, Japan

Yosuke Kaneko

Laboratory of Animal Technologist, Animal Care Co Ltd, Tokyo, Japan

Common marmosets were used as model animals for methylmercury (MeHg) poisoning. Six marmosets were given MeHg of 5 ppm Hg in drinking water. The animals were divided into 3 groups of 2 each. The first group was examined for acute symptomatic MeHg poisoning. They were given MeHg for 70 and 90 days, respectively, to manifest severe symptoms. The second group was sacrificed after 38 days of MeHg exposure, when they had acute-subclinical MeHg poisoning. The third group of animals was exposed for 21 days, and then observed for 2.5 years without MeHg exposure. One of them showed typical symptoms of MeHg poisoning after MeHg exposure had ended, but the other one showed only slight symptoms without ataxia. This experiment demonstrated that MeHg causes pathological changes in neural tissues including the peripheral nerves in common marmosets. Furthermore, common marmosets were found to show MeHg-induced pathological changes similar to those in humans in the cerebrum and cerebellum.

Key Words: Methylmercury • common marmoset • MRI (magnetic resonance imaging) • peripheral neuropathy • axonal degeneration.


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