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Toxicologic Pathology
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A Spontaneous Mutation: Amelogenesis Imperfecta with Cysts in Rats

Osamu Katsuta

Mitsubishi Chemical Safety Institute Ltd., Ibaraki-ken, Japan, osamu.katsuta{at}santen.co.jp

Nobuhito Hoshino

Mitsubishi Chemical Safety Institute Ltd., Ibaraki-ken, Japan

Midori Takeda

Mitsubishi Chemical Safety Institute Ltd., Ibaraki-ken, Japan

Akihiro Ono

Mitsubishi Chemical Safety Institute Ltd., Ibaraki-ken, Japan

Minoru Tsuchitani

Mitsubishi Chemical Safety Institute Ltd., Ibaraki-ken, Japan

Amelogenesis imperfecta (AI) is an inherited dental disease of enamel formation in humans, and there are various phenotypes due to the combination of enamel quality and quantity. We encountered four female IGS rats with spontaneous AI including odontogenic cysts in the incisor teeth. Histopathologically, in the incisors of the rats, the enamel organ was disorganized with the remaining enamel matrix residing within the enamel space. The expanding cysts derived from the enamel organ were formed in the periosteal connective tissue on the labial side. At the bottom of the tooth germs, the precursor cells of the epithelial root sheath were arranged regularly and the enamel organs were preserved to the same degree as those of normal rats. In the molar teeth of the affected rats an enamel matrix remained on the neck and crown of the erupted teeth; however, no abnormality was observed at the tooth root. Although an animal model of AI has been developed from mutants of the SHR-SP rat strain, the present cases represent another potential model of the disease because of the differences in the way the enamel matured and the odontogenic cyst formation in the incisors.

Key Words: Animal model • amelogenesis imperfecta • odontogenic cyst • amelogenin • IGS rats.

Toxicologic Pathology, Vol. 31, No. 4, 411-416 (2003)
DOI: 10.1080/01926230390202344
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