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Toxicologic Pathology, Vol. 31, No. 5, 468-470 (2003)
DOI: 10.1080/01926230390228940

An Alternative Perspective: A Critical Evaluation of the Waddell Threshold Extrapolation Model in Chemical Carcinogenesis

J.K. Haseman

Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709

In a recent Perspective article (Toxicologic Pathology 31: 260—262, 2003) Waddell asserts that he has developed a log linear extrapolation model that can demonstrate a threshold and resolve for once and for all the uncertainies associated with low dose cancer risk extrapolation. However, his method essentially forces, rather than demonstrates, a threshold, and has many serious flaws that result in significant under-estimation of low dose risk. It would be a serious mistake for the scientific community to adopt Waddell's log linear extrapolation model for chemical carcinogenesis risk assessment.

Key Words: Carcinogenesis • thresholds • extrapolation • risk assessment.


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