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Toxicologic Pathology
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Malignant Myoepithelioma with a Squamous Epithelial Component in the Mammary Gland of a Cynomolgus Monkey

Xiuying Yang

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan, xyyang{at}snbl.co.jp

Takao Hori

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan

Ayako Fukuda

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan

Yasuhiro Kamimura

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan

Kimiaki Hirakawa

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan

Hiroshi Maeda

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan

Hiroaki Miyajima

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan

A solid mass arising from the mammary gland was found in a 7-year-old female cynomolgus monkey. Histologically, the mass consisted of 2 components: spindle-shaped or ovoid sarcomatous cells and squamous epithelial cells. Metastatic nodules noted in the lung, liver and the gallbladder had the same histological features as the mammary mass. Immunohistochemistry revealed that the sarcomatous cells were positive for alpha-smooth muscle actin ({alpha}-SMA), vimentin, calponin, S-100 protein, epithelial membranous antigen (EMA), cytokeratin (large spectrum) and cytokeratin 14 (CK 14) in the cytoplasm, and p53, erbB-2 and progesterone receptor in the nuclei, but negative for desmin and estrogen receptor. The squamous epithelial cells were positive for EMA, cytokeratin (large spectrum) and CK 14, but negative for the rest. Both sarcomatous and squamous epithelial components were negative for glial fibrillary acidic protein (GFAP). Based on histological and immunohistochemical features, the present case was diagnosed as a malignant myoepithelioma with a squamous epithelial component in the mammary gland with distant metastases.

Key Words: Malignant myoepithelioma • squamous metaplasia • mammary gland • cynomolgus monkey • immunohistochemical staining.

Toxicologic Pathology, Vol. 31, No. 5, 549-553 (2003)
DOI: 10.1080/01926230390226672
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