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Toxicologic Pathology
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Applications of Magnetic Resonance Microscopy

Robert R. Maronpot

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, Maronpot{at}niehs.nih.gov

Robert C. Sills

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA

G. Allan Johnson

Duke Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710, USA

Magnetic resonance imaging (MRI) has enjoyed enormous clinical success since the first demonstration of the method more than 30 years ago. An increasing number of pharmaceutical manufacturers seeking new biomarkers for assessing drug efficacy and toxicity are turning to MRI. A specific application of MRI promises to revolutionize pathology for the basic scientist in the same way MRI has forever altered the standard of care in the clinical domain. More specifically, this application is the use of magnetic resonance microscopy (MRM) in conjunction with new staining methodologies that now make MRM routinely available to the widest range of investigators.

Key Words: Mouse • imaging • phenotype • MRI • rat • carbonyl sulfide.

Toxicologic Pathology, Vol. 32, No. 2 suppl, 42-48 (2004)
DOI: 10.1080/01926230490451707
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