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Toxicologic Pathology, Vol. 32, No. 2 suppl, 49-58 (2004)
DOI: 10.1080/01926230490451734

Digital Microscopy Imaging and New Approaches in Toxicologic Pathology

Bruce Mccullough

Aventis, Drug Safety Evaluation, Bridgewater, New Jersey 08807, USA, Bruce.McCullough{at}aventis.com

Xiaoyou Ying

Aventis, Drug Safety Evaluation, Bridgewater, New Jersey 08807, USA

Thomas Monticello

Aventis, Drug Safety Evaluation, Bridgewater, New Jersey 08807, USA

Marc Bonnefoi

Aventis, Drug Safety Evaluation, Bridgewater, New Jersey 08807, USA

Digital microscopy, a comprehensive integration of digital imaging and light microscopy, can assist the pathologist to observe, acquire, record, share, analyze, and manage pathology image data. To lead the activity for establishing new generation digital microscopy capacity, novel concepts and strategies of digital pathology information flow and digital pathology platform were designed to integrate personal digital pathology microscopy workstations and other pathology imaging modalities with centralized data storage/management. In addition, a strategy for Web-enabled interactive telepathology that would permit global capacity was designed. A novel concept of high content pathology was also created to develop an automated tissue microscopy imaging and screening approach. These new concepts, strategies, and approaches guided the development and implementation of a digital pathology platform, a telepathology platform, and automated tissue slide imaging capacity. Digital microscopy photography is now able to replace photographic film in toxicologic pathology. Digital pathology and telepathology platforms can provide a networked environment for multisite, global team participation. Our practice also ascertained the central value of digital microscopy which can provide innovative quantitative pathology information and data mining capability with various imaging biomarkers via advanced digital image processing and pathology informatics; these are now the focus of ongoing development.

Key Words: Digital microscopy • telepathology • automated tissue imaging • tissue image analysis • imaging biomarker • high content pathology • quantitative histopathology.


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Home page
 Toxicol PatholHome page
X. Ying and T. M. Monticello
Modern Imaging Technologies in Toxicologic Pathology: An Overview
Toxicol Pathol, December 1, 2006; 34(7): 815 - 826.
[Abstract] [Full Text] [PDF]