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Toxicologic Pathology
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Pathophysiological Effects of Chronic Toxicity with Synthetic Pyrethroid, Organophosphate and Chlorinated Pesticides on Bone Health of Broiler Chicks

Umesh K. Garg

Department of Veterinary Pathology, Faculty of Veterinary Science & Animal Husbandry, Birsa Agricultural University, Ranchi 834007, India

Asim K. Pal

Department of Veterinary Pathology, Faculty of Veterinary Science & Animal Husbandry, Birsa Agricultural University, Ranchi 834007, India, Central Institute of Fisheries Education, Agricultural Research Service, 7 Bungalows, Versova, Mumbai 400 061(M.S.), India

Gautam J. Jha

Department of Veterinary Pathology, Faculty of Veterinary Science & Animal Husbandry, Birsa Agricultural University, Ranchi 834007, India

Sanjay B. Jadhao

Central Institute of Fisheries Education, Agricultural Research Service, 7 Bungalows, Versova, Mumbai 400 061(M.S.), India, jsanju{at}hotmail.com

This experiment evaluated effects following chronic toxicity with 20 ppm fenvalerate (synthetic pyrethroid), 2 ppm monocrotophos (organophosphate) and 2 ppm endosulfan (chlorinated hydrocarbon) on bone health of broiler chicks. A total of 120 chicks were divided equally into 4 groups and were fed poultry mash without (control) or mixed with different pesticides for 8 weeks. Body mass, serum calcium and phosphorus levels were unaffected due to pesticides treatment. However, an increase (p < 0.01) in serum alkaline phosphatase activity was noted and serum total protein decreased (p < 0.01) in all treated groups. Roentogenography revealed destructive changes in the upper part of the femur in the monocrotophos group. Endosulfan intoxicated chicks had increased numbers of trabeculae in the medullary cavity. Microscopic alterations of the costochondral junction in intoxicated chicks were similar. The zones of proliferating, maturing and degenerating, and calcifying cartilage cells were reduced in width and the metaphysis in treated birds showed a reduced number of cartilage cells and thinner trabeculae. Due to toxicity, the capillary scaffolding of the degenerating cartilage cells was reduced and a larger number of transverse trabeculae could be seen in the metaphysis. Appositional bone growth studied by the tetracyclicline labeling technique indicated decreased active osteons.

Key Words: Pesticides • chronic toxicity • broiler chicks • bone health.

Toxicologic Pathology, Vol. 32, No. 3, 364-369 (2004)
DOI: 10.1080/01926230490431745
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