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Toxicologic Pathology
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Two Cases of Adreno-Hepatic Fusion in Cynomolgus Monkeys (Macaca fascicularis)

Sien Mousa

Organon, Department of Toxicology and Drug Disposition, 5340 BH Oss, The Netherlands, sien.mousa{at}organon.com

Eric Van Esch

Organon, Department of Toxicology and Drug Disposition, 5340 BH Oss, The Netherlands

In this report we describe 2 cases of adreno-hepatic fusion (AHF) in Cynomolgus monkeys (Macaca fascicularis ) used in short-term toxicity studies. AHF is defined as the union of hepatic tissue with the adrenal gland with close intermingling of the respective parenchymal cells. In this condition, a continuous intervening connective tissue septum is lacking. AHF is believed to be a congenital anomaly caused by a defect or delay in the formation of the organ capsules from the intermediate primitive mesenchymal stroma. To our knowledge, this is the first time this anomaly is described in the monkey.

Key Words: Adreno-hepatic fusion • adrenal gland • liver • cynomolgus monkey.

Toxicologic Pathology, Vol. 32, No. 5, 511-513 (2004)
DOI: 10.1080/01926230490496294
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