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Toxicologic Pathology
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Protective Activity of Hesperidin and Lipoic Acid Against Sodium Arsenite Acute Toxicity in Mice

Ricardo N. Pires Das Neves

CICECO, Department of Biology, Campus de Santiago, University of Aveiro, 3810-193 Aveiro, Portugal

Félix Carvalho

REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, 4099-033 Porto, Portugal

Márcia Carvalho

REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, 4099-033 Porto, Portugal

Eduarda Fernandes

REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, 4099-033 Porto, Portugal

Elisa Soares

REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, 4099-033 Porto, Portugal

Maria De Lourdes Bastos

REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, 4099-033 Porto, Portugal

Maria De Lourdes Pereira

CICECO, Department of Biology, Campus de Santiago, University of Aveiro, 3810-193 Aveiro, Portugal, lpereira{at}bio.ua.pt

The objective of the present work was to evaluate the toxic effects of sodium arsenite, As(III), in mice and the protective effect of 2 antioxidants, hesperidin and lipoic acid, against the observed As(III)-induced toxicity. In each study, mice were assigned to 1 of 4 groups: control, antioxidant, antioxidant + arsenite, and arsenite. Animals were first injected with the vehicle or 25 mg antioxidant/kg BW. After 30 minutes they received an injection of 10 mg arsenite/kg BW or 0.9% NaCl. Two hours after the first injection, the liver, kidney, and testis were collected for histological evaluation. Liver samples were also taken for quantification of arsenic. In mice exposed only to As(III), various histopathological effects were observed in the liver, kidneys, and testes. In mice pretreated with either hesperidin or lipoic acid, a reduction of histopathologic effects on the liver and kidneys was observed. No protective effects were observed in the testes for either of the 2 studied antioxidants. In conclusion, hesperidin and lipoic acid provided protective effects against As(III)-induced acute toxicity in the liver and kidneys of mice. These compounds may potentially play an important role in the protection of populations chronically exposed to arsenic.

Key Words: Hesperidin • lipoic acid • sodium arsenite • histopathology • mice • liver • kidney • testis.

Toxicologic Pathology, Vol. 32, No. 5, 527-535 (2004)
DOI: 10.1080/01926230490502566
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