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Toxicologic Pathology
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Articles

The Effects of Ad Libitum Feeding and Marked Dietary Restriction on Spontaneous Skeletal Muscle Pathology in Sprague–Dawley Rats

Sylvain Molon-Noblot1, Marie-Françoise Hubert1, Chao-Min Hoe2, Kevin Keenan3 and Philippe Laroque1

1 Merck Sharp & Dohme-Chibret Laboratories, Research Center, Department of Safety Assessment, Clermont-Ferrand Cedex 9, France
2 Merck Research Laboratories, Department of Biometrics, West Point, Pennsylvania 19486, USA
3 Merck Research Laboratories, Department of Safety Assessment, West Point, Pennsylvania 19486, USA

Correspondence: Address correspondence to: Dr. Sylvain Molon-Noblot, Merck Sharp & Dohme-Chibret Laboratories, Research Center, Department of Safety Assessment, Route de Marsat, Riom 63963, Clermont-Ferrand Cedex 9, France; e-mail: sylvainmolonnoblot{at}merck.com

The effects of ad libitum (AL) feeding and marked dietary restriction (DR) on spontaneous age-related skeletal muscle changes in male Sprague–Dawley (SD) rats were evaluated at 1 and 2 years. SD rats were fed Certified UAR A04C Rodent Chow ad libitum (AL), or DR at 50% of AL for (106 weeks). Body weights and organ weights were measured at the 1-year interim and 2-year final necropsies. In addition to the routine histopathologic examination, determination of 5 stereologic parameters was done in the vastus lateralis muscle after histochemistry of ATPase activity at 1 and 2 years. Body and skeletal muscle weights were proportional to the food intake. In AL-fed rats, muscle weights decreased between 1 and 2 years, in correlation with decreased type 2 myofiber numbers. In this group, fibrovascular index markedly increased with aging and muscle degeneration occurred at 2 years. In DR rats, there were no significant changes in muscle weights between 1 and 2 years. No histopathological changes were observed and the fibrovascular index was unchanged. These results demonstrated a protective effect of DR on the age-related skeletal muscle pathology in SD rats.

Key Words: Dietary restriction • aging • skeletal • muscle • sarcopenia

Toxicologic Pathology, Vol. 33, No. 5, 600-608 (2005)
DOI: 10.1080/01926230500251428
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