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Toxicologic Pathology
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Articles

Extraskeletal Osteosarcoma with Cystic Appearance in an Aged Sprague–Dawley Rat

Katsuhiko Yoshizawa1, Masahiro Matsumoto1, Yuji Oishi1 and Abraham Nyska2

1 Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc., Kashima 2-1-6, Yodogawa, Osaka, Japan
2 Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

Correspondence: Address correspondence to: Katsuhiko Yoshizawa, Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma, Inc., Kashima 2-1-6, Yodogawa, Osaka 532-8514, Japan; e-mail:katsuhiko.yoshizawa{at}jp.astellas.com

Extraskeletal osteosarcoma, arising spontaneously from the subcutis of the left abdomen and having a cystic appearance, was found in an untreated male Sprague–Dawley rat during a carcinogenicity study. At 76 weeks of age, the tumor mass had grown to 50 x 110 x 140 mm, and the animal exhibited severe anemia related to the complication of ulceration with hemorrhage. The tumor displayed irregular ossification at the walls of a cyst-like space filled with much yellowish fluid and necrotic cellular debris. Histopathologically, the tumor consisted of sheets of large, plump osteoblast-like cells, which produced broad irregular trabeculae of osteoid and calcified osseous tissue. Since extraskeletal osteosarcoma with a cystic appearance, has not been reported in animals, except for the telangiectatic type, our case shows an extremely rare type.

Key Words: Spontaneous tumor • extraskeletal osteosarcoma • cystic appearance • myositis ossificans • rat

Toxicologic Pathology, Vol. 33, No. 7, 762-765 (2005)
DOI: 10.1080/01926230500417052
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