Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 34, No. 1, 105-110 (2006)
DOI: 10.1080/01926230500369535

Articles

Echocardiographic Characterization of the Cardiovascular Phenotype in Rodent Models

Brian D. Hoit

University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA

Correspondence: Address correspondence to: Brian D. Hoit, Department of Medicine, Division of Cardiology, 11100 Euclid Avenue, Cleveland, OH 44106-5038, USA; e-mail:bdh6{at}po.cwru.edu

Echocardiographic techniques are commonly utilized to describe the rodent cardiovascular phenotype. These approaches are contrasted with other in vivo methods and are positioned in the assay selection process by a review of studies from our laboratory and others. Although not conventionally considered a biomarker, the technique has the potential to be exploited as a marker of intentional or unanticipated toxic biological effects in the preclinical development of drugs and chemicals.

Key Words: Color M-mode • rat TEE • MPI • tissue Doppler


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