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Imaging Methods for Morphological and Functional Phenotyping of the Rodent Heart
1 Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710, USA Correspondence: Address correspondence to: Cristian T. Badea, Box 3302, Duke University Medical Center, Durham, NC 27710, USA; e-mail:chris{at}orion.duhs.duke.edu Small animal imaging has a critical role in phenotyping, drug discovery, and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to compare two cardiac imaging modalities, i.e., magnetic resonance microscopy (MRM) and microcomputed tomography (CT) for preclinical studies on rodents. We present the two technologies, the parameters that they can measure, the types of alterations that they can detect, and show how these imaging methods compare to techniques available in clinical medicine. While this paper does not refer per se to the cardiac risk assessment for drug or chemical development, we hope that the information will effectively address how MRM and micro-CT might be exploited to measure biomarkers critical for safety assessment.
Key Words: Cardiac imaging • micro-CT • magnetic resonance microscopy • mouse Abbreviations: 2D, 2-dimensional • 3D, 3-dimensional • 4D, 4-dimensional • CT, computed tomography • LV, left ventricle • MI, myocardial infarction • MR, magnetic resonance • MRM, magnetic resonance microscopy • PET, positron emission tomography • rf, radio frequency • SNR, signal-to-noise ratio • SSFP, steady state free precession
Toxicologic Pathology, Vol. 34, No. 1,
111-117 (2006) This article has been cited by other articles:
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