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Sudden Cardiac Death not Related to Coronary Atherosclerosis
1 CVPath, International Registry of Pathology, Inc., Gaithersburg, MD 20878, USA Correspondence: Address correspondence to: Dr. Renu Virmani, International Registry of Pathology, 19 Firstfield Road, Gaithersburg, MD 20878, USA; e-mail:rvirmani{at}cvpath.org Sudden cardiac death (SCD) accounts for approximately 300,000 cardiac events in the United States each year, representing an overall incidence of 0.1–0.2% per year. Although the vast majority of these may be attributed to coronary atherosclerosis, a wide variety of nonatherosclerotic-related cardiac diseases have been associated with SCD. This review highlights three general categories of cardiac disease not related to atherosclerosis: the cardiomyopathies, inflammatory myocardial diseases, and ion channel disorders. The important role played by genetics in some of these cardiovascular diseases is presented as well as toxic and drug-related etiologies.
Key Words: Cardiomyopathy • myocarditis • molecular genetics • sudden cardiac death • toxicology Abbreviations: SCD, Sudden cardiac death • HCM, Hypertrophic cardiomyopathy • ARVD, Arrhythmogenic right ventricular dypsplasia • LVNC, Left ventricular noncompaction • PCR, Polymerase chain reaction • LQTS, Long Q-T syndrome
Toxicologic Pathology, Vol. 34, No. 1,
52-57 (2006) |
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