| Sign In to gain access to subscriptions and/or personal tools. |
Incidental Mononuclear Cell Infiltrate in the Uvea of Cynomolgus MonkeysDepartment of Drug Safety and Metabolism, Schering-Plough Research Institute, Lafayette, New Jersey 07848, USA Correspondence: Address correspondence to: Dinesh P. Sinha, Schering-Plough Research Institute, P.O. Box 32, 144 Route 94, Lafayette, New Jersey 07848, USA; e-mail:dineshwar.sinha{at}spcorp.com Mononuclear cell infiltrate (MCI) in the uvea was observed in naïve, untreated (control group) cynomolgus monkeys in approximately 25% of drug safety evaluation studies. The total incidence of MCI in the choroid and the ciliary body was 29% of 342 males and 25% of 306 female monkeys. In the studies in which MCI was present in the ciliary body or choroid, the incidence was as high as 75%. There were no other ocular histopathologic findings in these monkeys. All monkeys were clinically healthy and the eyes were not remarkable when examined ophthalmoscopically.
Key Words: Mononuclear cell infiltrate in the uveam • uveitis • choroiditis • ciliary body • choroids • iris • ocular changes in cynomolgus monkeys Abbreviations: MCI, Mononuclear cell infiltrate
Toxicologic Pathology, Vol. 34, No. 2,
148-151 (2006) This article has been cited by other articles:
|
|
|||||||||||||||
 |
|
|
 |
|
Sign In to gain access to subscriptions and/or personal tools.
