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Toxicologic Pathology
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Ectopic Uterine Ovarian Tissue in Cynomolgus Monkeys

Yuki Kuwamura, Kimiyo Kakehi, Kimiaki Hirakawa and Hiroaki Miyajima

Pathology Center, Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Osaka 541-0044, Japan

Correspondence: Address correspondence to: Yuki Kuwamura, Pathology Center, Shin Nippon Biomedical Laboratories, Ltd., Sumitomo Mitsui Banking Corporation Korai-bashi Building, 2-1-1 Fushimi-machi, Chuo-ku, Osaka 541-0044, Japan; e-mail:Kuwamura-yuki{at}snbl.co.jp

Spontaneous ectopic uterine ovarian tissue was found in 9 of 118 cynomolgus monkeys (Macaca fascicularis), an incidence of 7.6%. These ectopic tissues were minute and were incidentally observed in the parametrium by microscopic examination. They were composed of primordial or primary follicles and ovarian stroma. Ectopic ovarian tissue may result from disturbed migration of the ovarian primordium during embryogenesis.

Key Words: Ectopic ovarian tissue • uterus • cynomolgus monkey • macaca fascicularis • histopathology • spontaneous

Toxicologic Pathology, Vol. 34, No. 3, 220-222 (2006)
DOI: 10.1080/01926230600695482
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 Toxicol PatholHome page
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Selected Background Findings and Interpretation of Common Lesions in the Female Reproductive System in Macaques
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