Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text Free
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kai, K.
Right arrow Articles by Furuhama, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kai, K.
Right arrow Articles by Furuhama, K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Articles

Species and Sex Differences in Susceptibility to Olfactory Lesions Among the Mouse, Rat and Monkey Following an Intravenous Injection of Vincristine Sulphate

Kiyonori Kai
Hiroshi Sahto
Mitsuyoshi Yoshida
Takami Suzuki
Yukari Shikanai
Tetsuyo Kajimura
Kazuhisa Furuhama

Drug Safety Research Laboratory, Daiichi Pharmaceutical Company Ltd., Tokyo 134-8630, Japan

Correspondence: Address correspondence to: Kiyonori Kai, Daiichi Pharmaceutical Co. Ltd., Drug Safety Research Laboratory, 1-16-13, Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan; e-mail:kaikitrx{at}daiichipharm.co.jp

Species and sex differences in susceptibility to vincristine sulphate (VCR)-induced olfactory epithelial lesions were investigated among the BALB/c mice, Crj: CD(SD) IGS rats and common marmoset monkeys following a single intravenous administration on day 1. As dosage levels, the 0.17-fold LD10, 0.6-fold LD10 and LD10 were used for mice and rats, and a maximum tolerated dose (MTD) was chosen only for monkeys. The order of strength of VCR action on peripheral neuropathic signs, body weight gain, and hematological parameters was mice > rats > monkeys, without clear sex differences. Histopathologically, on day 2, single cell death in the olfactory epithelium and vomeronasal organ was observed only in male mice at LD10, and in female mice at 0.6-fold LD10 or more. On day 5, the olfactory epithelium in these mice showed regenerative proliferation suggesting a sign of recovery. On day 10, axonopathy and demyelination in the sciatic and trigeminal nerves were noted in mice of both sexes at 0.6-fold LD10 or more. In rats and monkeys of either sex, however, no morphological changes were observed at any dose level. In conclusion, mice, particularly females, were shown to be more susceptible to VCR-induced apoptosis in the olfactory epithelium than rats and monkeys.

Key Words: Mice • olfactory lesions • monkeys • rats • vincristine sulphate

Toxicologic Pathology, Vol. 34, No. 3, 223-231 (2006)
DOI: 10.1080/01926230600695557
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
R. Renne, A. Brix, J. Harkema, R. Herbert, B. Kittel, D. Lewis, T. March, K. Nagano, M. Pino, S. Rittinghausen, et al.
Proliferative and Nonproliferative Lesions of the Rat and Mouse Respiratory Tract
Toxicol Pathol, December 1, 2009; 37(7_suppl): 5S - 73S.
[Abstract] [Full Text] [PDF]