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Toxicologic Pathology
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Comparative Expression and Distribution of c-fos, Estrogen Receptor{alpha} (ER{alpha}), and p38{alpha} in the Uterus of Rats, Monkeys, and Humans

Zaher A. Radi and Nasir K. Khan

Worldwide Safety Sciences, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA

Correspondence: Address correspondence to: Zaher A. Radi, Worldwide Safety Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA; e-mail:zaher.radi{at}pfizer.com

The uterine cellular expression and distribution of c-fos, ER{alpha} and p38{alpha} was compared in humans, nonhuman primates, and rats using immunohistochemistry. ER{alpha} and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evident between proliferative and secretory cycle phases. In rats, the highest and lowest expression of c-fos was present during proestrus and estrus, respectively, in the LE and GE. The most intense ER{alpha} staining in rats was observed during proestrus in the GE, while the least intense staining was seen in the LE during proestrus. Strong LE and GE expression of p38{alpha} as present in rats in all stages of the estrous cycle and during the proliferative phase in both humans and nonhuman primates. No p38{alpha} expression was observed during the secretory phase in either humans or nonhuman primates. Our work suggests that c-fos, ER{alpha} and p38{alpha} (a) are primarily expressed during the proliferative phase, but not the secretory phase and exhibit interspecies expression variability, and (b) rats exhibit cyclic changes in the expression of c-fos and ER{alpha}.

Key Words: c-fos • estrogen receptor{alpha} • human • p38{alpha} • primate • rat • uterus

Toxicologic Pathology, Vol. 34, No. 4, 327-335 (2006)
DOI: 10.1080/01926230600773941
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