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Toxicologic Pathology
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Articles

Spontaneous Lesions of the Cardiovascular System in Purpose-Bred Laboratory Nonhuman Primates

Ronnie Chamanza1, Nicola M. A. Parry2, Petrina Rogerson1, Jen R. Nicol1 and Alys E. Bradley1

1 Charles River Laboratories, Preclinical Services Edinburgh, Tranent, Scotland EH33 2NE, United Kingdom
2 Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA

Correspondence: Address correspondence to: Ronnie Chamanza, Charles River Laboratories, Preclinical Services Edinburgh, Tranent, Scotland EH33 2NE, United Kingdom; e-mail:ronnie.chamanza{at}eur.crl.com

This retrospective study was performed to determine the range, occurrence and incidence of spontaneously arising histopathological findings of the cardiovascular system in purpose-bred laboratory nonhuman primates. Data were collected from 84 controlled toxicological studies with equal numbers of male and female animals and full tissue lists. Attempts were also made to standardize pathological terms used by various original pathologists. Tissue sections from 2464 animals, which included 2050 cynomolgus monkeys (Macaca fascicularis), 284 common marmosets (Callithrix jacchus) and 130 rhesus monkeys (Macaca mulatta) were examined. The most common cardiac finding was focal myocardial inflammation, subcategorized as either "inflammatory cell infiltration" (339) or "focal myocarditis" (131). Other cardiac findings included mineralization (29), endocarditis (16), pericarditis (10), squamous cysts (6) and ectopic thyroid tissue (5). Perivasculitis/vasculitis in the kidney, lung, meninges, sciatic nerve, and other tissues (206) was the most common vascular lesion. Focal myocarditis was more common in male (60%) than female (40%) animals. Cardiac mineralization and extramedullary hematopoiesis were more common in marmosets than other species while ectopic thyroid tissue was present in marmosets and cynomolgus monkeys. To our knowledge, this is the first study to demonstrate the range and incidence of spontaneous cardiovascular lesions in laboratory nonhuman primates.

Key Words: Cardiovascular • spontaneous pathology • nonhuman primate • cynomolgus • rhesus • marmoset

Toxicologic Pathology, Vol. 34, No. 4, 357-363 (2006)
DOI: 10.1080/01926230600809737
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