Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 34, No. 5, 609-615 (2006)
DOI: 10.1080/01926230600867735

Articles

Histopathology of Mucosa-Associated Lymphoid Tissue

C. Frieke Kuper

TNO Nutrition and Food Research, 3704 HE Zeist, The Netherlands

Correspondence: Address correspondence to: C. Frieke Kuper, TNO Nutrition and Food Research, P.O. Box 360, 3704 HE Zeist, The Netherlands; e-mail:frieke.kuper{at}tno.nl

Mucosa-associated lymphoid tissue (MALT) is a generalized term incorporating a disseminated collection of lymphoid tissues in multiple sites throughout the body. MALT sites that have been/are primarily studied include bronchus-associated lymphoid tissue (BALT), gut-associated lymphoid tissue (GALT), and nasopharynx-associated lymphoid tissue (NALT). Since MALT sites are often under-sampled in conventional toxicity studies, MALT lesions have not been extensively documented in these lymphoid effector sites. Lesions of the nasopharyngeal lymphoid tissue and Peyer’s patches include degeneration, inflammation, and both primary and metastatic neoplasia.

Key Words: Lymphatic ectasia • macrophage aggregates • granulomas • MALT lymphoma


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