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Apoptosis: A Review of Programmed Cell Death

NIEHS, Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA

Correspondence: Address correspondence to: Susan Elmore, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA; e-mail:elmore{at}niehs.nih.gov

The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. The ability to modulate the life or death of a cell is recognized for its immense therapeutic potential. Therefore, research continues to focus on the elucidation and analysis of the cell cycle machinery and signaling pathways that control cell cycle arrest and apoptosis. To that end, the field of apoptosis research has been moving forward at an alarmingly rapid rate. Although many of the key apoptotic proteins have been identified, the molecular mechanisms of action or inaction of these proteins remain to be elucidated. The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptosis in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptosis.

Key Words: Apoptosis • programmed cell death • intrinsic/extrinsic pathway • granzyme A/B • perforin • autophagy

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