Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 35, No. 5, 672-675 (2007)
DOI: 10.1080/01926230701481881

Articles

An Undifferentiated Sarcoma in a Rat Resembling Extraskeletal Myxoid Chondrosarcoma in Man

Keigo Nakamura, Kazumoto Shibuya, Takuya Hirai and Tetsuo Nunoya

Nippon Institute for Biological Science, Tokyo 198-0024, Japan

Correspondence: Address correspondence to: Keigo Nakamura, Nippon Institute for Biological Science, 9–2221–1 Shinmachi, Ome, Tokyo 198–0024, Japan; e-mail:k-nakamura{at}nibs.or.jp

A soft tissue tumor occurring in the inguinal subcutaneous tissue was detected in a 109-week-old male F344 rat. Macroscopically, the tumor mass showed no skeletal relationship and a gelatinous multinodular appearance. Histologically, the tumor consisted of irregular lobules separated by scant fibrous septa. In each lobule, tumor cells were arranged in cords and strands in the plentiful myxoid stroma. The tumor cells showed marked pleomorphism, and had large, round to ovoid nuclei and abundant eosinophilic cytoplasm. Mitotic figures were often seen. Myxoid stroma of the tumor contained a large amount of acid mucopolysaccharides and collagen type II, which were demonstrated by histochemistry and immunohistochemistry respectively. The tumor cells showed positive immunoreactivities for vimentin and S100 protein. Ultrastructural examination revealed that the tumor cells had a large amount of mitochondria, Golgi complex and dilated rough endoplasmic reticulum containing amorphous material, and the myxoid stroma contained collagenous fibrils and proteoglycan particles. Based on these results, the present tumor in a rat resembled extraskeletal myxoid chondrosarcoma in man.

Key Words: Acid mucopolysaccharides • chondroblast • collagen type II • extraskeletal myxoid chondrosarcoma • F344 rat

Abbreviations: HE, hematoxylin and eosin • AB, alcian blue • PAS, periodic acid-Schiff • SMA, smooth muscle actin • MBP, myelin basic protein • GFAP, glial fibrillary acidic protein • vWF, von Willebrand factor • PBS, phosphate-buffered saline • WSS, wide spectrum screening • EDTA, ethylenediaminetetracetic acid


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