Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 35, No. 6, 767-779 (2007)
DOI: 10.1080/01926230701584189
© 2007 Society of Toxicologic Pathology

Invited Review

Novel Insights into Wound Healing Sequence of Events

Liora Braiman-Wiksman1, Inessa Solomonik1, Ram Spira3 and Tamar Tennenbaum1,2

1 Heal-Or Ltd. Ness Ziona Science Park, Israel
2 Bar-Ilan University Ramat-Gan, Israel
3 Shaare-Zedek Medical Center Jerusalem Israel

Correspondence: Address correspondence to: Tamar Tennenbaum, CEO and Founder, HealOr Ltd. Ness Ziona Science Park, POB 1550, Ness Ziona, Israel; e-mail:tamar{at}healor.com

Effective wound healing leads to restoration of tissue integrity and occurs through a highly organized multistage process involving various cell types. Currently, methods for wound healing assessment lack a structured system for analysis of quantitative parameters. We have established a unique quantitative assessment strategy of wound healing stages based on histological criteria. Distinctive immunohistochemical parameters including re-epithelialization, epidermal differentiation, cell migration, proliferation, inflammatory response as well as dermal closure, matrix distribution, and skin remodelling were identified and followed during the timeline of wound healing progression. Assessment was based on various defined characteristics and each stage-specific parameter was independently quantified for complete wound closure. This analysis allowed a follow-up of wound healing dynamics and identified the contribution of critical and specific parameters to wound healing physiology and pathology. In this review we demonstrate our assessment strategy of crucial wound healing events and introduce a unique quantification system for each of the processes involved in wound repair. We believe that our unique method can be utilized as a diagnostic platform for standardizing assessment of wound healing progression as well as a screening tool for potential therapies.

Key Words: Skin • wound healing • quantitative assessment • reepithelialization • matrix

Abbreviations: K1, keratin 1 • K6, keratin 6 • K14, keratin 14 • H&E, hematoxylin and eosin staining • PCNA, proliferating cell nuclear antigen • NOD, non-obese diabetic mice • STZ, streptozotocine • HGF, hepatocytes growth factor • KGF, keratinocytes growth factor • TGFbeta, transforming growth factor beta • PDGF, platelet derived growth factor • IGF1, insulin-like growth factor 1 • IL1, interleukine 1 • betaFGF, beta fibroblast growth factor


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