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Toxicologic Pathology
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Brief Communication

Chronic Phenobarbital-Induced Mitochondrial Pleomorphism in the Rat Liver

Zakaria Almsherqi1, Craig Steven Mclachlan1,2, Stacey K. H. Tay, 2,3 and Yuru Deng1

1 Department of Physiology, National University of Singapore, Yong Loo Lin School of Medicine, Singapore 117597
2 Genetic Medicine Group, Center for Molecular Medicine, A*STAR, Singapore 136668
3 Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074

Correspondence: Address correspondence to: Yuru Deng, Department of Physiology, Faculty of Medicine National University of Singapore, Block MD9, 2 Medical Drive Singapore 117597; e-mail:phsdy{at}nus.edu.sg

Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.

Key Words: Mitochondria • phenobarbital • liver • rat • electron microscopy • ultrastructure

Toxicologic Pathology, Vol. 35, No. 6, 831-833 (2007)
DOI: 10.1080/01926230701584171
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