Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 35, No. 7, 1010-1012 (2007)
DOI: 10.1080/01926230701481949

Articles

An Occurrence of Multiple Carcinomas in Both Kidneys of a 5-year-old Female Cynomolgus Monkey (Macaca fascicularis)

Yuko Yamaguchi, Toru Hoshiya, Kosuke Horiguchi and Kazutoshi Tamura

Division of Pathology, BOZO Research Center Inc, Gotemba-shi, Shizuoka 412-0039, Japan

Correspondence: Address correspondence to Yuko Yamaguchi, Division of Pathology, BOZO Research Center Inc, 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan; e-mail:path{at}bozo.co.jp

An occurrence of multiple carcinoma in both kidneys of a 5-year-old female cynomolgus monkey is described in the present paper. Macroscopically, the kidneys were enlarged with multiple solid and grayish-white masses and cysts mainly in the cortex and outer medulla. Light microscopically, carcinomas showed either tubulopapillary or tubulosolid growth patterns. Carcinoma cells were pleomorphic cuboidal to columnar cells. Cytoplasm was abundant and either granular and eosinophilic or clear, and nuclei were large and vesicular with prominent nucleoli. Electron microscopy revealed the existence of a brush border-like structure on the cell surface of carcinoma cells, suggesting that carcinoma cells arose from proximal tubular epithelial cells. Small foci of tubular epithelial cell hyperplasia and adenomas were also observed independently of carcinomas. There was no evidence of transition from adenoma to carcinoma, and no metastases were detected.

Key Words: Renal cell carcinoma • cynomolgus monkey • bilateral • multiple


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