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Toxicologic Pathology, Vol. 35, No. 7, 865-879 (2007)
DOI: 10.1080/01926230701618516
© 2007 Society of Toxicologic Pathology

A Critical Comparison of Murine Pathology and Epidemiological Data of TCDD, PCB126, and PeCDF

Katsuhiko Yoshizawa

Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc., Yodogawa, Osaka 532-8514, Japan, Pathology , Kansai Medical University, Moriguch, Osaka 570-8506, Japan

Allison Heatherly

Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709, USA

David E. Malarkey

Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709, USA

Nigel J. Walker

Environmental Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709, USA

Abraham Nyska

Toxicologic Pathologist, Timrat 23840, Israel, anyska{at}bezeqint.net

2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD, or dioxin) and dioxin-like compounds (DLCs) induce numerous toxicities, including developmental, endocrine, immunological, and multi-organ carcinogenic, in animals and/or humans. Multiple studies completed by the National Toxicology Program (NTP) focused on the effects caused in Harlan Sprague-Dawley rats by specific DLCs, among them the prototypical dioxin, TCDD. Because humans are exposed daily to a combination of DLCs, primarily via ingestion of food, the Toxic Equivalency Factor (TEF) was developed in order to evaluate health hazards caused by these mixtures. Herein we review the pathological effects reported in humans exposed to TCDD; 3,3',4,4',5-pentachlorobiphenyl (PCB 126); and 2,3,4,7,8,-pentachlorodibenzofuran (PeCDF) and compare them to similar changes seen in NTP murine studies performed with the same compounds. While there were differences in specific pathologies observed, clear consistency in the target organs affected (liver, oral cavity, cardiovascular system, immune system, thyroid, pancreas, and lung) could be seen in both human studies and rodent toxicity and carcinogenicity investigations.

Key Words: Carcinogenesis • dioxin • human • PCB126 • PeCDF • rodent • TCDD.


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