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Toxicologic Pathology
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Preparation of Medical Devices for Evaluation

Serge Rousselle
Joan Wicks

From HSRL, Mount Jackson, Virginia, USA

Correspondence: Address correspondence to: Serge Rousselle, HSRL, 5930 Main Street, Mount Jackson, VA 22842; e-mail: srousselle{at}hsrl.org.

Preparing and processing medical device implants for evaluation is a relatively high-risk and high-dollar process in which studies get made and endpoints can be lost with no second chance. It is important to customize every aspect of the preparation process to the type of device and the study endpoints. Some standard and proven approaches for a few types of implants are discussed, addressing fixation, special dissection and extraction techniques, preprocessing imaging, trimming techniques, sample processing, embedding media, and cutting and staining options.

Key Words: Cardiovascular system • immunohistochemistry • medical devices • musculoskeletal system

Abbreviations: CT, computed tomography • GMA, glycomethacrylate acetate • HE, hematoxylin and eosin • IHC, immunohistochemistry • MMA, methylmethacrylate acetate • PAS, periodic acid - Schiff

Toxicologic Pathology, Vol. 36, No. 1, 81-84 (2008)
DOI: 10.1177/0192623307310962
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