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Toxicologic Pathology
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Articles

Spontaneous Rhabdomyosarcoma in a Young Sprague-Dawley Rat

Shih-Chieh Chang1, Kosei Inui2, Wei-Cheng Lee3, Shih-Ling Hsuan3, Maw-Sheng Chien3, Chung-Hsin Chen3, Shi-Jan Chang3 and Jiunn-Wang Liao3

1 Department of Veterinary Medicine and Veterinary Medical Teaching Hospital, National Chung-Hsing University, Taichung, Taiwan, ROC
2 Central Research Institute (K.I), Ishihara Sangyo Kaisha Ltd., Shiga, Japan
3 Graduate Institute of Veterinary Pathobiology, National Chung-Hsing University, Taichung, Taiwan, ROC

Correspondence: Jiunn-Wang Liao, DVM., PhD, Associate Professor, National Chung-Hsing University, Graduate Institute of Veterinary Pathobiology, 250, Kuokuang Road, Taichung 402, Taiwan, ROC; e-mail:jwliao{at}dragon.nchu.edu.tw.

An eight-week-old male Sprague-Dawley (SD) rat showed signs of emaciation, and masses were found in the subcutis around the cervical and thoracic regions. At necropsy, a multilobular mass, 2.2 x 1.8 x 2.0 cm in size, had grown from the left neck into the thoracic cavity. On a cutting surface, masses were firm and whitish to tan, with necrotic and hemorrhagic plaques. Microscopically, masses were composed of multiple nodules of tumor cells that were incompletely encapsulated with fibrous connective tissue. The tumor cells exhibited varied forms, from spindle to globoid shapes with minimal to abundant eosinophilic cytoplasm, and appeared as large, multinucleated cells; many of the tumor cells were vacuolated. Histochemistry results revealed that tumor cells exhibited some cross-striation in the cytoplasm using PTAH staining. There were some multinuclear tumor cells with vacuoles located around the nuclei, and these vacuoles showed reddish staining by the periodic acid Schiff (PAS) method. Immunohistochemical staining also expressed intense granular cytoplasmic staining for desmin and myoglobin, with highly positive staining for PCNA, whereas {alpha}-smooth muscle actin ({alpha}-SMA) was negative. Based on the pathology results, a spontaneous rhabdomyosarcoma with pleomorphic type was diagnosed in a young SD rat.

Key Words: rhabdomyosarcoma • spontaneous • pleomorphic • young • Sprague-Dawley rat • rodent

Abbreviations: {alpha}-SMA, {alpha}-smooth muscle actin • MT, Masson Trichrome staining • PAS, periodic acid Schiff staining • PCNA, proliferating cell nuclear antigen • PTAH, phosphotungstic acid hematoxylin staining

This version was published on October 1, 2008

Toxicologic Pathology, Vol. 36, No. 6, 866-870 (2008)
DOI: 10.1177/0192623308323623
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