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Toxicologic Pathology
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Articles

Variability in Weight and Histological Appearance of the Prostate of Beagle Dogs Used in Toxicology Studies

Laëtitia Dorso, Franck Chanut, Paul Howroyd and Roger Burnett

MDS Pharma Services, Drug Safety Assessment, Les Oncins, 69210 Saint-Germain-sur-L’Arbresle, France

Correspondence: Address correspondence to: Franck Chanut, MDS Pharma Services, Drug Safety Assessment, Les Oncins, 69210 Saint-Germain-Sur-L’Arbresle, France; e-mail:Franck.Chanut{at}mdsinc.com.

This review was performed to assess variations in weight and histologic appearance of the prostate of untreated male beagle dogs between 23 and 108 weeks of age, from two breeding centers. Data from 125 control beagle dogs from twenty-seven regulatory toxicology studies were used. Age, terminal body weight, and prostate weight were analyzed. Prostate sections were examined microscopically, and histological changes—such as development of acini, amount of secretion, and patterns of dilation and inflammation—were recorded and graded when appropriate. The influence of age, terminal body weight, and source on the weight and histological appearance of the prostate, and the degree of interanimal variation were evaluated

Key Words: prostate • beagle dog • histology • body weight • maturation • preclinical safety evaluation

This version was published on December 1, 2008

Toxicologic Pathology, Vol. 36, No. 7, 917-925 (2008)
DOI: 10.1177/0192623308324958
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