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Spontaneous Ganglioneuroma Possibly Originating from the Trigeminal Ganglion in a B6C3F1 MousePathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan Correspondence: Kazuhiro Toyoda, Pathology Department, Biosafety Research Center, Foods Drugs and Pesticides, 582-2 Shioshinden, Iwata, Shizuoka 437-1213, Japan; e-mail:k-toyoda{at}anpyo.or.jp. In a carcinogenicity study, a neuronal tumor in the cranial cavity was observed in a 110-week-old female B6C3F1 mouse. At necropsy, the tumor was seen at the site of the pituitary gland. Histologically, the tumor consisted of well-differentiated ganglion cells, nerve fiber/neuropil-like elements and ganglion-like cells. The tumor was composed mainly of ganglion-like cells, which were arranged in solid sheets interspersed with thin fibrovascular stroma. Nissl substance was detected at the margin in the cytoplasm of well-differentiated ganglion cells, and nerve fibers were identified by the Kluever-Barrera method. Immunohistochemically, the well-differentiated ganglion cells were positive for S-100, neurofilament protein (NF), neuron-specific enolase (NSE), synaptophysin, and chromogranin A. The nerve fiber/neuropil-like elements were positive for S-100, NF, NSE, and glial fibrillary acidic protein (GFAP), and the ganglion-like cells were strongly positive only for NSE and synaptophysin. On the other hand, there were no pituitary cells, such as prolactin-positive or adrenocorticotropic hormone (ACTH)-positive cells in the tumor tissue. Detailed histopathological examination suggested that the tumor might be a ganglioneuroma arising from the trigeminal ganglion. This report provides additional histopathological evidence of peripheral nerve neoplasms in mice.
Key Words: ganglioneuroma • mouse • pituitary gland • trigeminal ganglion
Toxicologic Pathology, Vol. 37, No. 3,
343-347 (2009) |
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