Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0192623309338384v1
37/5/667    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ramot, Y.
Right arrow Articles by Nyska, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramot, Y.
Right arrow Articles by Nyska, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Articles

Spontaneous Aortitis in the Balb/c Mouse

Yuval Ramot1, Rose Anna Manno2, Yoshimasa Okazaki3, Michael Krakovsky4, Itschak Lamensdorf4, Moran Meiron5, Amir Toren5, Efrat Zehavi-Goldstein5, Enrico Vezzali2 and Abraham Nyska6

1 Hadassah–Hebrew University Medical Center, Jerusalem, Israel
2 RTC S.p.A., I-00040 Pomezia, Rome, Italy
3 Astellas Pharma Inc., Toxicologic Pathology, Drug Safety Research Laboratories, Kashima 2-1-6, Yodogawa, Osaka 532-8514, Japan
4 Pharmaseed Ltd., Ness-Ziona, 74047, Israel
5 Pluristem Therapeutics Inc., Haifa, Israel
6 Consultant in Toxicological Pathology, Timrat, and Sackler School of Medicine, Tel Aviv University, Israel

Correspondence: Address correspondence to: Abraham Nyska, D.V.M., Dipl. ECVP, Haharuv 18, P.O. Box 184, Timrat, Israel 36576; e-mail:anyska{at}bezeqint.net.

We examined whether high incidence rates (18%–56%) of inflammation in the root of the aorta detected in a Balb/c mouse model for hind limb ischemia were related to the surgical procedure. Twenty mice underwent ligation of the femoral artery; incidences of aortic root inflammation were compared to those observed in controls. We used a multiple-section sampling method to increase the sensitivity of the diagnostic rates. Although a cumulative incidence of 12.5% was found, no difference was seen in the overall incidence rates between the control and the surgically treated groups. Evaluation of blood levels of inflammatory cytokines showed that ligation of the femoral artery produced higher levels of interleukin-6 in the surgically transected group of mice. The development of spontaneous arteritis in this strain must be considered in future studies.

Key Words: limb ischemia • inflammation • aortitis • Balb/c

Abbreviations: IFN-{gamma}, interferon-{gamma} • IL, interleukin • IM, intramuscular • TNF-{alpha}, tumor necrosis factor-{alpha}

This version was published on August 1, 2009

Toxicologic Pathology, Vol. 37, No. 5, 667-671 (2009)
DOI: 10.1177/0192623309338384
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Vet PatholHome page
Noteworthy
Vet. Pathol., November 1, 2009; 46(6): 1311 - 1312.
[Full Text] [PDF]