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Toxicologic Pathology
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Journal Article

Naturally Occurring Granular Cell Tumors of the Brain in Rats

H. C. Chen, D.V.M.

Haskell Laboratory for Toxicology and Industrial Medicine, E. I. du Pont de Nemours & Company, Inc., Wilmington, Delaware

E. F. Stula, D.V.M., Ph.D.

Haskell Laboratory for Toxicology and Industrial Medicine, E. I. du Pont de Nemours & Company, Inc., Wilmington, Delaware

A retrospective study was conducted to determine the incidence of granular cell tumors of the brain in ChR-CD rats, used as controls in two-year toxicity studies conducted at Haskell Laboratory (1971-73). Two (1.6%) such tumors were found in 127 male rats, 13 to 25 months of age. No granular cell tumors of the brain were found in 128 female ChR-CD rats, 13 to 25 months of age. These appear to be the first reported cases of granular cell tumors of the brain in this strain of Sprague-Dawley rat.

Toxicologic Pathology, Vol. 7, No. 1, 15-18 (1979)
DOI: 10.1177/019262337900700103
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