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Toxicologic Pathology
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Journal Article

The Interfering Effects of Hemolyzed Blood on Rat Serum Chemistry

Byong Han Chin, Ph.D.

Diamond Shamrock Corporation, Department of Safety Assessment, T. R. Evans Research Center, P.O. Box 348, Painesville, Ohio 44077

Tipton R. Tyler

Chemical Hygiene Fellowship, Carnegie-Mellon Institute of Research, Carnegie-Mellon University, 4400 Fifth'Avenue, Pittsburgh, PA 15213

Sarah J. Kozbelt

Chemical Hygiene Fellowship, Carnegie-Mellon Institute of Research, Carnegie-Mellon University, 4400 Fifth'Avenue, Pittsburgh, PA 15213

The influence of Hb on 14 serum constituents was evaluated. Among the 7 enzymes for which analyses were conducted, LD and HBD values were elevated fivefold at the highest Hb concentration of 1500 mg/liter. Hb had less of an effect on the activities of other enzymes, i.e., AST activity was increased by only 30% whereas CK activity was decreased by 10%. Among the 7 nonenzymatic constituents of rat serum studied, a Hb concentration of 1500 mg/liter resulted in a fivefold increase in total bilirubin concentration. Creatinine and glucose values were negatively correlated to Hb concentrations but the dependence was not nearly as great as that with total bilirubin. The remaining serum constituents studied were not affected by Hb concentrations.

Toxicologic Pathology, Vol. 7, No. 1, 19-22 (1979)
DOI: 10.1177/019262337900700104
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This article has been cited by other articles:


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 Toxicol PatholHome page
J. H. Riley
Clinical Pathology: Preanalytical Variation in Preclinical Safety Assessment Studies-Effect on Predictive Value of Analyte Tests
Toxicol Pathol, January 1, 1992; 20(3-2): 490 - 500.
[Abstract] [PDF]

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 Toxicol PatholHome page
B. H. Chin, S. J. Kozbelt, and L. J. Sullivan
Measurement of 14 Blood Components in Rats, Dogs, and Mice Using CentrifichemR Analyzer
Toxicol Pathol, February 1, 1979; 7(2): 10 - 13.
[Abstract] [PDF]