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Table 2A Highest and lowest 10 ranked genes from consensus principal component analysis.
| Rank |
Gb Acc. |
Category |
Gene name |
Correl |
|
| 1 |
AA859846 |
Structure |
Actin, beta |
0.881 |
| 2 |
AA964725 |
Structure |
Weak sim to pervin |
0.842 |
| 3 |
AA964496 |
Structure |
High sim to S11222 actin gamma, cytoskeletal [Rat] |
0.853 |
| 4 |
AA957078 |
Structure |
Alpha-tubulin |
0.842 |
| 5 |
AA924111 |
Glycolysis |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) |
0.811 |
| 6 |
AI029162 |
APR |
Orosomucoid 1 |
0.885 |
| 8 |
AA997175 |
Signal transd. |
Casein kinase II beta subunit |
0.835 |
| 10 |
AA900726 |
Signal transd. |
GTP-binding protein (ral A) |
0.789 |
| 552 |
AI070895 |
Fatty acid metab. |
Weakly sim. to acyl-CoA dehydrog., epoxide hydr.[Cel] |
–0.735 |
| 553 |
AA866389 |
Other |
Lumican |
–0.865 |
| 554 |
AA964340 |
Other |
Syndecan 2 |
–0.747 |
| 555 |
AA955402 |
Cysteine metab |
S-adenosylhomocysteine hydrolase |
–0.776 |
| 556 |
AA925933 |
Proteolysis |
Cathepsin S |
–0.801 |
| 557 |
AA819756 |
Drug metab |
Arachidonic acid epoxygenase; CYP2C23 |
–0.888 |
| 558 |
AI136048 |
Cholest.metab |
3-Hydroxy-3-methylglutaryl- Coenzyme A synthase 2 |
–0.821 |
| 559 |
AI071033 |
Acute phase |
Fibrinogen, B beta polypeptide |
–0.820 |
| 560 |
AA997322 |
Cholest.metab |
Lecithin-cholesterol acyltransferase (LCAT) |
–0.745 |
| 561 |
AA997920 |
Signal transd. |
Asialoglycoprotein receptor 2 |
–0.900 |
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Rank, gene name and Genbank accession number, category, and the correlation to the degree of hepatic necrosis are indicated. Expression of high ranked genes is increased, while low ranked genes are decreased in the samples with a high degree of hepatic necrosis.
Toxicol Pathol, Vol. 33, No. 4,
425-433 (2005)
DOI: 10.1080/01926230590958146
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