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Chemical Carcinogens Without Mutagenic Activity: Peroxisome Proliferators As A Prototype

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Dante G. Scarpelli

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Vadrevu Subbarao

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Narendra D. Lalwani

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Chemical carcinogens can be classified into two categories (i.e. mutagenic and non-mutagenic) on the basis of positive or negative evidence of DNA damage, mutagenicity or chromosomal aberrations in short-term test systems. Evidence indicates that carcinogenic peroxisome proliferators are negative in short-term test systems. This paper outlines approaches which may be useful in identifying a chemical carcinogen without mutagenic activity. It is conceivable that an alteration in DNA, if essential for initiation of neoplasia, may be mediated indirectly by the biological effects of nonmutagenic carcinogens.

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Toxicologic Pathology, Vol. 11, No. 2, 172-180 (1983)
DOI: 10.1177/019262338301100209


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Reddy, J. K. Articles by Lalwani, N. D. Search for Related Content PubMed PubMed Citation Articles by Reddy, J. K. Articles by Lalwani, N. D. Social Bookmarking                         What's this?