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Nuclear Structure and Higher Order Gene Structure: Their Role in the Control of Chemically-Induced Neoplastic Transformation

Biophysics Division, Temple University, Philadelphia, Pennsylvania

An overview is hereby given of the physical and physicochemical alterations at the level of nuclear structures in rat liver cells, following a chemically-induced neoplastic transformation. These alterations refer to chromatin-DNA structure, from secondary (B- versus A- and Z-form) to tertiary-quanternary up to quinternary (in situ), and to the physical state of water. Possible molecular mechanisms-linking global chromatin changes to single gene expression in the control of neoplastic transformation-are discussed in terms of the degree of negative superhelicity of fibrosomes, recently identified single repeating structural sub-units and hereby associated with single functional genes.

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Toxicologic Pathology, Vol. 12, No. 2, 149-154 (1984)
DOI: 10.1177/019262338401200206


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nicolini, C. Search for Related Content PubMed PubMed Citation Articles by Nicolini, C. Social Bookmarking                         What's this?