Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Yamasaki, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamasaki, H.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal Article

Cell-Cell Interaction and Carcinogenesis

Hiroshi Yamasaki

International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon cedex 08, France

Before carcinogenic stimuli are introduced, a potentially cancerous cell functions normally; growth is controlled and the cell exists in complete harmony with that of surrounding cells in a given tissue. During the process of multi-stage carcinogenesis, such harmony is destroyed and a presumptive initiated cell accomplishes a clonal expansion, neglecting the growth pattern of surrounding normal cells. Recent results from our own laboratory and others strongly suggest that blocked gap-junctional intercellular communication is an important determinant during the process of tumor promotion.

  • 1. Atkinson MM, Menko AS, Johnson RG, Sheppard JR, and Sheridan JD (1981). Rapid and reversible reduction of junctional permeability in cells infected with a temperature-sensitive mutant of avian sarcoma virus. J. Cell Biol. 91: 573–578.[Abstract/Free Full Text]
  • 2. Blumberg PM (1980). In vitro studies on the mode of action of the phorbol esters, potent tumor promoters. Crit. Rev. Toxicol. 8: 153–234.[Medline] [Order article via Infotrieve]
  • 3. Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, and Nishizuka Y (1982). Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257: 7847–7851.[Abstract/Free Full Text]
  • 4. Cohen R, Pacifici M, Rubenstein N, Biehl J, and Holtzer H (1977). Effect of a tumor promoter on myogenesis. Nature 266: 538–540.[CrossRef][Medline] [Order article via Infotrieve]
  • 5. Davidson JS, Baumgarten IM, and Harley EH (1985). Effects of 12-O-tetradecanoylphorbol-13-acetate and retinoids on intercellular junctional communication measured with a citrulline incorporation assay. Carcinogenesis 6: 645–650.[Abstract/Free Full Text]
  • 6. Dorman BH and Boreiko CJ (1983). Limiting factors of the V79 cell metabolic cooperation assay for tumor promoters. Carcinogenesis 4: 873–877.[Abstract/Free Full Text]
  • 7. Dorman BH, Butterworth BE, and Boreiko CJ (1983). Role of intercellular communication in the promotion of C3H10T1/2 cell transformation. Carcinogenesis 4: 1109–1115.[Abstract/Free Full Text]
  • 8. Driedger PE and Blumberg PM (1980). Specific binding of phorbol ester tumor promoters. Proc. Natl. Acad. Sci. USA 77: 567–571.[Abstract/Free Full Text]
  • 9. Enomoto T, Martel N, Kanno Y, and Yamasaki H (1984). Inhibition of cell communication between BALB/c 3T3 cells by tumor promoters and protection by cAMP. J. Cell. Physiol. 121: 323–333.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 10. Enomoto T, Sasaki Y, Shiba Y, Kanno Y, and Yamasaki H (1981). Tumor promoters cause a rapid and reversible inhibition of the formation and maintenance of electrical cell couping in culture. Proc. Natl. Acad. Sci. USA 78: 5628–5632.[Abstract/Free Full Text]
  • 11. Enomoto T and Yamasaki H (1984). Lack of intercellular communication between chemically transformed and surrounding non-transformed BALB/c 3T3 cells. Cancer Res. 44: 5200–5203.[Abstract/Free Full Text]
  • 12. Enomoto T and Yamasaki H (1985). Rapid inhibition of intercellular communication by diacylglycerol, a possible endogenous functional analog of phorbol esters. Cancer Res. 45: 3706–3710.[Abstract/Free Full Text]
  • 13. Enomoto T and Yamasaki H (1985). Phorbol estermediated inhibition of intercellular communication in BALB/c 3T3 cells: Relationship to enhancement of cell transformation. Cancer Res. 45: 2681–2688.[Abstract/Free Full Text]
  • 14. Finbow ME, Shuttleworth J, Hamilton AE, and Pitts JD (1983). Analysis of vertebrate gap junction protein. EMBO J. 2: 1479–1486.[Web of Science][Medline] [Order article via Infotrieve]
  • 15. Fitzgerald DJ, Knowles SE, Ballard FJ, and Murray AW (1983). Rapid and reversible inhibition of junctional communication by tumor promoters in a mouse cell line. Cancer Res. 43: 3614–3618.[Abstract/Free Full Text]
  • 16. Friedman EA and Steinberg M (1982). Disrupted communication between late-stage premalignant human colon epithelial cells by 12-O-tetradecanoyl-phorbol-13-acetate. Cancer Res. 42: 5096–5105.[Abstract/Free Full Text]
  • 17. Gainer HS and Murray AW (1985). Diacyglycerol inhibits gap junctional communication in cultured epidermal cells: Evidence for a role of protein kinase C. Biochem. Biophys. Res. Commun. 126: 1109–1113.[CrossRef]
  • 18. Kakunaga T (1973). A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB/c 3T3. Int. J. Cancer 12: 463–473.[Web of Science][Medline] [Order article via Infotrieve]
  • 19. Kakunaga T and Crow JD (1980). Cell variants showing differential susceptibility to ultraviolet light-induced transformation. Science 209: 505–507.[Abstract/Free Full Text]
  • 20. Kakunaga T, Hamada H, Leavith J, Crow JD, Hirakawa T, and Lo KY (1982). Evidence for both mutational and nonmutational process in chemically induced cell transformation. In: Mechanisms of Chemical Carcinogenesis, CC Harris and PA Cerutti (eds). Alan R. Liss, New York, pp. 517–529.
  • 21. Kalimi GH and Sirsat SM (1984). Phorbol esters tumor promoter affects the mouse epidermal gap junctions. Cancer Lett. 22: 343–350.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 22. Kinsella AR (1982). Elimination of metabolic cooperation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents. Carcinogenesis 3: 499–503.[Abstract/Free Full Text]
  • 23. Lo KY and Kakunaga T (1982). Similarities in the formation and removal of covalent DNA adducts in benzo(a)pyrene-treated BALB/3T3 variant cells with different induced transformation frequencies. Cancer Res. 42: 2644–2650.[Abstract/Free Full Text]
  • 24. Loewenstein WR (1979). Junctional intercellular communication and the control of growth. Biochim. Biophys. Acta 560: 1–65.[Medline] [Order article via Infotrieve]
  • 25. Murray WA and Fitzgerald JD (1979). Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells. Biochem. Biophys. Res. Commun. 91: 395–401.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 26. Newbold RF and Amos J (1981). Inhibition of metabolic cooperation between mammalian cells in culture by tumor promoters. Carcinogenesis 2: 243–249.[Abstract/Free Full Text]
  • 27. Niedel JE, Kuhn LJ, and Vandenbark GR (1983). Phorbol diester receptor copurifies with protein kinase C. Proc. Natl. Acad. Sci. USA 80: 36–40.[Abstract/Free Full Text]
  • 28. Nishizuka Y (1984). The role of protein kinase C in cell surface signals transduction and tumor promotion. Nature 308: 693–698.[CrossRef][Medline] [Order article via Infotrieve]
  • 29. Rozengurt E, Rodriguez-Pena A, Coombs M, and Sinnett-Smith J (1984). Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: Role of Ca++-sensitive phospholipid-dependent protein kinase. Proc. Natl. Acad. Sci. USA 81: 5748–5752.[Abstract/Free Full Text]
  • 30. Sharkey NA, Leack KL, and Blumberg PM (1984). Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc. Natl. Acad. Sci. USA 81: 607–610.[Abstract/Free Full Text]
  • 31. Stanbridge EJ, Der CJ, Doersen CJ, Nishimi RY, Peehl DM, Weissman BE, and Wilkinson JE (1982). Human cell hybrids: Analysis of transformation and tumorigenicity. Science 215: 252–259.[Abstract/Free Full Text]
  • 32. Sugimoto Y, Whitman M, Cantley LC, and Erikson RL (1984). Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc. Natl. Acad. Sci. USA 81: 2117–2121.[Abstract/Free Full Text]
  • 33. Unwin PNT and Zampighi G (1980). Structure of the junction between communicating cells. Nature 283: 545–549.[CrossRef][Medline] [Order article via Infotrieve]
  • 34. Yamasaki H, Enomoto T, Martel N, Shiba Y, and Kanno Y (1983). Tumor promoter-mediated reversible inhibition of cell-cell communication (electrical coupling). Exp. Cell Res. 146: 297–308.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 35. Yamasaki H, Enomoto T, Shiba Y, Kanno Y, and Kakunaga T (1985). Intercellular communication capacity as a possible determinant of transformation sensitivity of BALB/c 3T3 clonal cells. Cancer Res. 45: 637–641.[Abstract/Free Full Text]
  • 36. Yancey SB, Edens JE, Trosko JE, Chang CC, and Revel JP (1982). Decreased incidence of gap junctions between Chinese hamster V79 cells upon exposure to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate. Exp. Cell Res. 19: 329–340.
  • 37. Yotti LP, Chang CC, and Trosko JE (1979). Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter. Science 206: 1089–1091.[Abstract/Free Full Text]

Toxicologic Pathology, Vol. 14, No. 3, 363-369 (1986)
DOI: 10.1177/019262338601400313
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Yamasaki, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamasaki, H.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?