|
Sign In to gain access to subscriptions and/or personal tools.
|
Structure and Function of the Immune System
Kevin T. Schultz
Department of Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Drive West, University of Wisconsin-Madison, Madison, Wisconsin 53706
Franziska Grieder
Department of Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Drive West, University of Wisconsin-Madison, Madison, Wisconsin 53706
The major function of the immune system is to protect the host from environmental agents such as microbes or chemicals, thereby preserving the integrity of the body. This is done by the recognition of self and response to non-self. The immune response has been artificially divided into innate immunity (resistance) and specific immunity. Specific immunity is further divided into humoral immunity, the one involved with antibody, and cellular immunity, which is orchestrated by T cells. It is essential to understand that although these divisions have helped in understanding and analyzing the immune response, the system functions as a single unit rather than as a separate entity. In this paper, a simplified analysis of specific immunity will be given. However, the importance of nonspecific immunity, especially as it pertains to its role in preventing exposure of environmental substances, should not be forgotten.
- 1. Audhya T, Bigbee JW, Bigbee JW, Bigbee JW, and Bigbee JW (1986). Tripeptide structure of Bursin, a selective B cell differentiating hormone of the Bursa of Fabricius. Science 231: 997–999.[Abstract/Free Full Text]
- 2. Bankert RB, Bigbee JW, and Bigbee JW (1982). Idiotypes; their presence on B- and T-lymphocytes and their role in the regulation of the immune response. Vet. Immuno. Immunopath. 3: 147–184.[CrossRef]
- 3. Corley RB, Bigbee JW, Bigbee JW, Bigbee JW, Bigbee JW, Bigbee JW, and Bigbee JW (1985). Three classes of signalling molecules on B-cell membranes. J. Cell. Biochem 27: 1–12.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- 4. Dinarello CA (1984). Interleukin-1 and the pathogenesis of the acute phase response. N. Eng. J. Med. 311: 413–418.[Web of Science][Medline]
[Order article via Infotrieve]
- 5. Durum SK, Bigbee JW, and Bigbee JW (1985). Interleukin-1: An immunological prospective. Ann. Rev. Immunol. 3: 263–287.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- 6. Hogg N (1986). Factor induced differentiation and activation of macrophages. Immunol. Today 7: 65–67.[CrossRef][Web of Science]
- 7. Jronvik K, and Bigbee JW (1980). The role of T cell growth stimulating factors in T cells triggering. Immunol. Rev. 51: 35–59.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- 8. Lafuse WP, and Bigbee JW (1984). IA antigens: Genes molecules and function. Transplantation 38: 443–453.[Web of Science][Medline]
[Order article via Infotrieve]
- 9. Milanese C, Bigbee JW, and Bigbee JW (1986). The identification of T helper cell derived lymphokine that activates resting T lymphocytes. Science 321: 1118–1122.
- 10. Muraguchi A, Bigbee JW, Bigbee JW, and Bigbee JW (1984). Regulation of human B cell activation, proliferation, and differentiation by soluble factors. J. Clin. Immunol. 4: 337–347.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- 11. Ratcliffe MJH (1985). The ontogeny and cloning of B cells in the Bursa of Fabricius. Immunol. Today 6: 223–227.[CrossRef][Web of Science]
- 12. Roitt I (1984). Essential Immunology. Blackwell Scientific Publications, London, England.
- 13. Roitt I, Bigbee JW, and Bigbee JW (1985). Immunology. Grower Medical Publishing, New York.
- 14. Schimpl A (1984). Lymphokines active in B-cell proliferation and differentiation. Springer Semin. Immunopath. 7: 297–310.
- 15. Wilson ME, Bigbee JW, and Bigbee JW (1985). The phagocytic cell: Summary. Rev. Inf. Diseases 7: 387–389.
Toxicologic Pathology, Vol. 15, No. 3,
262-264 (1987)
DOI: 10.1177/019262338701500301
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
|
|
