This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by House, R. V. Search for Related Content PubMed PubMed Citation Articles by House, R. V. Social Bookmarking                         What's this?

Cytokine Technology in Basic and Applied Research on the Hematopoietic System

Life Sciences Research, T Research Institute, 10 West 35th Street, Chicago, Illinois 60616

Cytokines are polypeptide molecules important for the regulation and maintenance of immunity and hematopoiesis. Their central role in the control of a number of physiological mechanisms makes them an important area of both basic and applied biomedical research. This review presents an overview of basic and applied biology, and introduces the term cytokine technology to denote the use of cytokines as research tools for understanding the cellular and molecular regulation of hematopoiesis. A number of frontier technologies are reviewed, including fusion toxins, fusion proteins, and animal models of cytokine expression and regulation.

Key Words: Lymphokine • bioassay • hematopoiesis • in vitro • bioprobes • alternative models

• Allen TD and Dexter TM (1984). The essential cells of the hemopoietic microenvironment. Exp. Hematol. 12: 517-521.[Web of Science][Medline] [Order article via Infotrieve]
• Arend AP (1991). Interleukin 1 receptor antagonist. J. Clin. Invest. 88: 1445-1451.[Web of Science][Medline] [Order article via Infotrieve]
• Boone T., Chazin V., Kenney W., Swanson E., and Altrock B. (1988). Construction, purification and biological activities of recombinant human interleukin-2 analogs. Develop. Biol. Standard. 69: 157-168.
• Brizzi MF, Avanzi GC, and Pegorano L. (1991). Hematopoietic growth factor receptors. Int. J. Cell Cloning 9:274-300.[Medline] [Order article via Infotrieve]
• Cohen RB, Siegel JP, Puri RK, and Pluznik DH (1992). The immunotoxicology of cytokines. In: Clinical Immunotoxicology, DS Newcombe, NR Rose, and JC Bloom (eds). Raven Press, New York, pp. 93-108.
• Curtis BM, Williams DE, Broxmeyer HE, et al (1991). Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein. Proc. Natl. Acad. Sci. USA 88: 5809-5813.[Abstract/Free Full Text]
• Dorshkind K. (1990). Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu. Rev. Immunol. 8: 111-137.[Web of Science][Medline] [Order article via Infotrieve]
• Fanslow WC, Sims JE, Sassenfeld H., et al (1990). Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor. Science 248: 739-742.[Abstract/Free Full Text]
• Greenberger JS (1991). Toxic effects on the hematopoietic microenvironment. Exp. Hematol. 19: 1101-1109.[Web of Science][Medline] [Order article via Infotrieve]
• Halpern MT (1991). Human nonspecific suppressive cytokines. J. Clin. Immunol. 11: 1-12.[Medline] [Order article via Infotrieve]
• Henderson B. and Blake S. (1992). Therapeutic potential of cytokine manipulation. TiPS 13: 145-152.[Medline] [Order article via Infotrieve]
• Krauser ED, Wadler S., and Thiel E. (1992). Interactions between cytokines and cytotoxic drugs: Putative molecular mechanisms in experimental hematology and oncology. Semin. Oncol. 19: 1-7.[Web of Science][Medline] [Order article via Infotrieve]
• LaMarre J., Wollenberg GK, Gonias SL, and Hayes MA (1991). Cytokine binding and clearance properties of proteinase-activated 2-macroglobulins. Lab. Invest. 65: 3-14.[Web of Science][Medline] [Order article via Infotrieve]
• Lange W., Brugger W., Rosenthal FM, Kanz L., and Lindemann A. (1991). The role of cytokines in oncology. Int. J. Cell Cloning 9: 252-273.[Medline] [Order article via Infotrieve]
• Lübbert M., Jonas D., and Herrmann F. (1990). Animal models for the biological effects of continuous high cytokine levels. Blut 61: 253-257.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Lyman SD and Williams DE (1992). Biological activities and potential therapeutic uses of Steel factor. Am. J. Ped. Hematol. Oncol. 14: 1-7.[Medline] [Order article via Infotrieve]
• Moore KW, Vieira P., Fiorentino DF, Trounstine ML, Khan TA, and Mosmann TR (1990). Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRF1. Science 248: 1230-1233.[Abstract/Free Full Text]
• Moore M. (1991). The clinical use of colony stimulating factors. Annu. Rev. Immunol. 9: 159-191.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Newman SL and Tucci MA (1990). Regulation of human monocyte/macrophage function by extracellular matrix. J. Clin. Invest. 86: 703-714.[Web of Science][Medline] [Order article via Infotrieve]
• Olsson I., Lantz M., and Richter J. (1992). The receptors for regulatory molecules of hematopoiesis. Eur. J. Haematol. 48: 1-9.
• Paetkau V. and Mills GB (1989). Cytokines and mechanisms of lymphocyte activation. Transplant. Immunol. 9: 21-43.
• Parkinson DR (1990). Lessons from the clinical trials of interleukin-2. Nat. Immun. Cell Growth Regul. 9: 242-252.[Web of Science][Medline] [Order article via Infotrieve]
• Shalaby MR, Halgunset J., Haugen OA, et al (1991). Cytokine-associated tissue injury and lethality in mice: A comparative study. Clin. Immunol. Immunopathol. 61:69-82.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Strom TB, Anderson PL, Rubin-Kelley VE, et al (1991). Immunotoxins and cytokine toxin fusion proteins. Ann. N.Y. Acad. Sci. 30: 233-250.
• Taniguchi T. (1988). Regulation of cytokine gene expression. Annu. Rev. Immunol. 6: 439-4.64.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Van Brunt J. (1991). Assaying cytokines. BioTechnology 9: 439-441.[CrossRef][Medline] [Order article via Infotrieve]
• Waldmann TA, Grant A., Tendler C., et al (1990). Lymphokine receptor-directed therapy: A model of immune intervention. J. Clin. Immunol. 10: 19S-29S.[CrossRef][Medline] [Order article via Infotrieve]
• Whetton AD and Dexter TM (1989). Myeloid haemopoietic growth factors. Biochim. Biophys. Acta 989: 111-132.[Medline] [Order article via Infotrieve]
• Whicher JT and Evans SW (1990). Cytokines in disease. Clin. Chem. 36: 1269-1281.[Abstract/Free Full Text]
• Williams DE, Park LS, Broxmeyer HE, and Lu L. (1991). Hybrid cytokines as hematopoietic growth factors. Int. J. Cell Cloning 9: 542-547.[Medline] [Order article via Infotrieve]

Toxicologic Pathology, Vol. 21, No. 2, 251-257 (1993)
DOI: 10.1177/019262339302100218


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by House, R. V. Search for Related Content PubMed PubMed Citation Articles by House, R. V. Social Bookmarking                         What's this?