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Toxicologic Pathology
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Review Article

Environmental Pathology: New Directions and Opportunities

Brooke T. Mossman

University of Vermont College of Medicine, Department of Pathology, Burlington, Vermont

The National Institute of Environmental Health Sciences (NIEHS) supports a number of training programs for predoctoral and postdoctoral (D.V.M., M.D., Ph.D.) fellows in toxicology, epidemiology and biostatistics, and environmental pathology. At the Experimental Biology meeting in April 1997, the American Society of Investigative Pathology (ASIP) sponsored a workshop including directors, trainees, and other interested scientists from several environmental pathology programs in medical and veterinary colleges. This workshop and a related session on "Novel Cell Imaging Techniques for Detection of Cell Injury" revealed advances in molecular and cell imaging approaches as reviewed below that have a wide applicability to toxicologic pathology.

Key Words: Cell biology • molecular biology • microscopy • cell imaging • careers • diagnostics

References

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  • Davis WP, Janssen Ymw, Mossman BT, and Taatjes DJ (1997). Simultaneous triple fluorescence detection of mRNA localization, nuclear DNA, and apoptosis in cultured cells using confocal laser scanning microscopy. Histochem. Cell Biol. 108: 307-311.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
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  • Fung H., Kow YW, Van Houten B, Taatjes DJ, Hatahet Z., Janssen Ymw, Vacek P., Faux SP, and Mossman BT (1998). Asbestos increases mammalian major AP-endonuclease (APE) gene expression, protein levels and enzyme activity in rat pleural mesothelial cells. Cancer Res. 58: 189-194.[Abstract/Free Full Text]
  • Goldberg JL, Zanella CL, Janssen Ymw, Timblin CR, Jimenez LA, Vacek P., Taatjes DJ, and Mossman BT (1997). Novel cell imaging approaches show induction of apoptosis and proliferation in mesothelial cells by asbestos. Am. J. Respir. Cell Mol. Biol. 17: 265-271.[Abstract/Free Full Text]
  • Kamentsky LA and Kamentsky LD (1991). Microscope-based multiparameter laser scanning cytometer yielding data comparable to flow cytometry data. Cytometry 12: 381-387.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pache JC, Janssen Ymw, Walsh ES, Quinlan TR, Zanella CL, Low RB, Taatjes DJ, and Mossman BT (1998). Increased epidermal growth factor-receptor (EGF-R) protein in a human mesothelial cell line in response to long asbestos fibers. Am. J. Pathol. 152: 333-340.[Abstract]
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  • Sewall CH, Clark GC, and Lucier GW (1995). TCDD reduces rat hepatic epidermal growth factor receptor: Comparison of binding, immunodetection, and autophosphorylation. Toxicol. Appl. Pharmacol. 132: 263-272.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Soultanakis RP, Cooper WC, Heintz NH, Mossman BT, and Janssen Ymw (1998). Cell cycle dependent expression of c-jun and c-jun-N-terminal kinase in rat lung epithelial cells and the effects of exposure to reactive oxygen or nitrogen species (ROS or RNS). Am. Rev. Respir. Crit. Care Med. 157: A453 (abstract).
  • Timblin CR, Janssen Ywm, and Mossman BT (1995). Transcriptional activation of the proto-oncogene c-jun, by asbestos and H2O2 is directly related to increased proliferation and transformation of tracheal epithelial cells. Cancer Res. 55: 2723-2726.[Abstract/Free Full Text]
  • Zanella CL, Posada J., Tritton TR, and Mossman BT (1996). Asbestos causes stimulation of the ERK-1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor. Cancer Res. 56: 5334-5338.[Abstract/Free Full Text]

Toxicologic Pathology, Vol. 27, No. 2, 180-186 (1999)
DOI: 10.1177/019262339902700205


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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mossman, B. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mossman, B. T.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?