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Chemical Hormesis: Its Historical Foundations as a Biological Hypothesis

Edward J. Calabrese

Department of Environmental Health Sciences, School of Public Health, University of Massachusetts, Amherst, Massachusetts

Linda A. Baldwin

Department of Environmental Health Sciences, School of Public Health, University of Massachusetts, Amherst, Massachusetts

Despite the long history of hormesis-related experimental research, no systematic effort to describe its early history has been undertaken. The present paper attempts to reconstruct and assess the early history of such research and to evaluate how advances in related scientific fields affected the course of hormesis-related research. The purpose of this paper is not only to satisfy this gap in current knowledge but also to provide a foundation for the assessment of how the concept of hormetic dose-response relationships may have affected the nature of the bioassay, especially with respect to hazard assessment practices within a modem risk assessment framework.

Key Words: Low dose • stimulation • β-curve

References

  • Allison RV, Bryan OC, and Hunter JH (1927). The stimulation of plant response on the raw peat soils of the Florida Everglades through the use of copper sulphate and other chemicals. Fla. Agric. Exp. Sta. Bull. 190: 35-80.
  • Aso K. (1906/1908). On a stimulating action of calcium fluoride on phaenograms. Bull. Coll. Agric. Tokyo 7: 90.
  • Barnes TC (1933). Further observations on the physiological effect of the heavy hydrogen isotope on spirogyra. Am. J. Bot. 20: 681-682.
  • Barnes TC (1933). A possible physiological effect of the heavy isotope of H in water. J. Am. Chem. Soc. 55: 4432-4433.
  • Becker A. (1926). Ueber den Einfluss der Samenbehandlung mit Reizchemikalien auf die Keimung und das Wachstum. Landwirtschaftliches Jahrbuch 63: 501-561.
  • Bertrand G. and Javillier M. (1911). Influence du manganese sure le developpement de l'Aspergillus niger. CR Acad. Sci. 152: 225-228.
  • Bokorny T. (1913). Uber den Einfluss verschiedener Substanzen auf die Keimung der Pflanzensamen. Wachstums Forderung durch einige. Biochem. Z. 51: 1-48.[Web of Science]
  • Branham SE (1929). The effects of certain chemical compounds upon the course of gas production by baker's yeast. J. Bacteriol. 18: 247.[Free Full Text]
  • Branham SE (1929). An improved technique for the comparison of antiseptics by yeast fermentation. J. Infect. Dis. 44: 142-149.[Web of Science]
  • Brenchley WE (1914). Inorganic Plant Poisons and Stimulants. Cambridge University Press, London.
  • Brenchley WE (1927). Inorganic Plant Poisons and Stimulants, 2nd ed. Cambridge University Press, London.
  • Brenchley WE (1936). The essential nature of certain minor elements for plant nutrition. Bot. Rev. II: 173-196.
  • Brown PE and Hitchcock EB (1917). The effects of alkali salts on nitrification. Soil Sci. 4: 207-229.
  • Buchanan RE and Fulmer EI (1930). Physiology and Biochemistry of Bacteria, Vol. II, Effects of Environment Upon Microorganisms. Williams & Wilkins, Baltimore.
  • Buchner E. and Rapp R. (1897). Alkoholische Gahrung ohne Hefezellen III. Ber. Dtsch. Chem. Ges. 30: 2668-2678.[CrossRef]
  • Buchner E. and Rapp R. (1898). Alkoholische Gahrung ohne Hefezellen IV. Ber. Dtsch. Chem. Ges. 31: 209-217.[CrossRef]
  • Buchner E. and Rapp R. (1898). Alkoholische Gahrung ohne Hefezellen V. Ber. Dtsch. Chem. Ges. 31: 1084-1090.[CrossRef]
  • Buchner E. and Rapp R. (1898). Alkoholische Gahrung ohne Hefezellen VI. Ber. Dtsch. Chem. Ges. 31: 1090-1094.
  • Buchner E. and Rapp R. (1899). Alkoholische Gahrung ohne Hefezellen IX. Ber. Dtsch. Chem. Ges. 32: 2086-2094.[CrossRef]
  • Calabrese EJ and Baldwin LA (1997). The dose determines the stimulation (and poison): Development of a chemical hormesis database. Int. J. Toxicol. 16: 545-559.[Abstract/Free Full Text]
  • Calabrese EJ and Baldwin LA (1997). A quantitatively-based methodology for the evaluation of chemical hormesis. Hum. Ecol. Risk Assess. 3: 545-554.
  • Clark JF (1899). Electrolytic dissociation and toxic effect. J. Phys. Chem. 3: 263-316.[CrossRef]
  • Clark JF (1899). On the toxic effect of deleterious agents on the germination and development of certain filamentous fungi. Bot. Gaz. 28: 289-327; 378-404.
  • Clark JF (1902). On the toxic properties of some copper compounds with special reference to bordeaux mixture. Bot. Gaz. 33: 26-48.
  • Clayton EE (1919). Hydrogen cyanide fumigation. Bot. Gaz. 67: 483-500.
  • Clifton CE (1957). Introduction to Bacterial Physiology. McGraw-Hill Book Company, Inc., New York.
  • Copeland EB (1903). Chemical stimulation and the evolution of carbon dioxide. Bot. Gaz. 35: 81-183.
  • Copeland EB and Kahlenberg L. (1899). The influence of the presence of pure metals upon plants. Wis. Acad. Sci. Arts Lett. 12: 454-474.
  • Coupin H. (1903). Sur la nutrition du sterigmatocystis nigra. CR CXXXVI: 392-394.
  • Delepine AS and Greenwood A. (1914). The action of some metals upon certain water and other bacteria. R. Sanit. Inst. J. 35: 317-327.
  • Duggar BM (1901). Physiological studies with reference to the germination of certain fungous spores. Bot. Gaz. 31: 38-66.
  • Eisenberg P. (1918). Untersuchgen uber spezigische desingektionsvorgange. II Mitt. Uber die wirkung von salzer und ionen auf bakterien. Centralbl. Bakt. Abt. (1, Orig) 82: 69-208.
  • Evans WH (1896). Copper sulphate and germination. Bulletin No. 10, U.S. Department of Agriculture, Division of Vegetable Physiology and Pathology, 24 pp.
  • Fabian FW and Bryan CS (1933). The influence of cations on aerobic sporogenesis in a liquid medium. J. Bacteriol. 26: 543-558.[Free Full Text]
  • Fabian FW and Winslow C-EA (1929). The influence upon bacterial viability of various anions in combination with sodium. J. Bacteriol. 18: 265-291.[Free Full Text]
  • Fairchild DG (1894). Bordeaux mixture as a fungicide. Bulletin No. 6, U.S. Department of Agriculture, Division of Vegetable Pathology, 55 pp.
  • Falk IS (1923). The role of certain ions in bacterial physiology. A review (Studies of Salt Action. VII). Abstr. Bacteriol. 7: 33-50; 87-105; 133-147.
  • Fitch R. (1906). The action of insoluble substances in modifying the effect of deleterious agents upon the fungi. Ann. Chim. Phys. 4: 313-322.
  • Gottbrecht C. (1886). Experimentalle Untersucheunge uber die Wirkung Thalliums. Greifswald, Inaugural Dissertation.
  • Greaves JE (1913). The influence of arsenic upon the biological transformation of nitrogen in soils. Biochem. Bull. 3: 2-16.
  • Greaves JE (1913). Stimulating influence of arsenic upon the nitrogen-fixing organisms of the soil. J. Agric. Res. 6: 389-416.
  • Greaves JE and Carter EG (1924). Influence of sodium arsenite on microflora of soil. Bot. Gaz. 77: 63-72.
  • Guenther E. (1897). Beitrag zur mineralischen Nahrung der Pilze. Inaugural Dissertion, Erlangen. Ref. Bot. Centralbl. 4: 194.
  • Harden A. (1911). Action of some inhibiting and accelerating agents on the enzymes of yeast-juice. In: Alcoholic Fermentation. Longmans. Green and Co., New York. pp. 64-74.
  • Harden A. and Young WJ (1906). The influence of sodium arsenate on the fermentation of glucose by yeast-juice. Proc. Chem. Soc. 22: 283-284 (preliminary notice).
  • Harter LL (1905). The variability of wheat varieties in resistance to toxic salts. Bulletin No. 79. U.S. Department of Agriculture, Bureau of Plant Industry.
  • Hayes WJ (1975). Factors influencing toxicity. In: Toxicology of Pesticides, Williams & Wilkins, Baltimore.
  • Haywood JK (1905). Injury to vegetation by smelter fumes. Bulletin No. 89, U.S. Department of Agriculture, Bureau of Chemistry, 23 pp.
  • Haywood JK (1908). Injury to vegetation and animal life by smelter fumes. Bulletin No. 113, U.S. Department of Agriculture, Bureau of Chemistry, 40 pp.
  • Haywood JK (1910). Injury to vegetation and animal life by smelter fumes. Bulletin No. 113 (Revised), U.S. Department of Agriculture, Bureau of Chemistry, 63 pp.
  • Heald FD (1896). On the toxic effect of dilute solutions of acids and salts upon plants. Bot. Gaz. 22: 125-153.
  • Hoffman G. (1884). Experimentalle Untersuchungen uber die Wirkung der Aneisensaure. Greifswald, Inaugural Dissertation.
  • Hofmann P. (1922). Ueber die Gultigkeit des Arndt-Schulzschen biologischen Grundgesetzes bei der Wirkung von Bakteriengiften. Inaugural Dissertation, Tierarztl. Fakultat. Munchen. (Translated from the German by University of Massachusetts translation services.)
  • Hotchkiss M. (1923). The influence of various salts upon the growth of bacterium communis. Yale University, Ph.D. dissertation.
  • Hotchkiss M. (1923). Studies on salt action. VI. The stimulating and inhibitive effect of certain cations upon bacteria growth. J. Bacteriol. 8: 141-162.[Free Full Text]
  • Hueppe F. (1896). Principles of Bacteriology. (Translated from the German by EO Jordan.) Open Court Publishing Company, Chicago.
  • Hune ( 1909). Die begunstigende Reizwirkung kleinster Mengen von Bakteriengiften auf die Bakterienvermehrung. Centralbl. Bakt. Abt. Orig. 48: 135.
  • Jacobi B. (1899). Ueber den Einfluss verschiedener Substanzen auf die Athmung und Assimilation suberser Pflanzen. Flora 86: 289-327.
  • Javillier M. (1907). Sur l'influence favorable del petites doses de zinc sur la vegetation de Sterigmatocystis nigra V. Tgh. CR CXLV: 1212-1215.
  • Jensen GH (1907). Toxic limits and stimulation effects of some salts and poisons on wheat. Bot. Gaz. 43: 11-44.
  • Jonsson B. (1896-1897). On the influence of arsenic on the germination of seeds. Exp. Sta. Rec. 8: 232-234.
  • Kahlenberg L. and True RH (1896). On the toxic action of dissolved salts and their electrolytic dissociation. Preliminary paper. JAMA. 27: 138-141.
  • Kahlenberg L. and True RH (1896). On the toxic action of dissolved salts and their electrolytic dissociation. Bot. Gaz. 22: 81-124.
  • Kearney TH and Cameron FK (1902). Some mutual relations between alkali soils and vegetation. Report No. 71, U.S. Department of Agriculture, U.S. Government Printing Office, Washington, D.C.
  • Klebs G. (1900). Einige Ergebnisse der Fortpflanzungs-Physiologie. Ber. Dtsch. Bot. Ges. 18: 201-215.
  • Lamanna C. and Mallette MF (1965). Basic Bacteriology: Its Biological and Chemical Background, 3rd ed. Williams & Wilkins, Baltimore.
  • Latham ME (1905). Stimulation of Sterigmatocystis by chloroform. Bull. Torrey Bot. Club 32: 337-351.[CrossRef]
  • Latham ME (1909). Nitrogen assimilation of Sterigmatocystis nigra and the effect of chemical stimulation. Bull. Torrey Bot. Club 36: 285.
  • Lindsay J. (1913). The elimination of algae in lochs and ponds. Trans. Edinb. Field Nat. Microsc. Soc. VI: 422-431.
  • Lipman CB (1909). Toxic and antagonistic effects of salts as related to ammonification by Bacillus Subtilis. Bot. Gaz. 48: 105-125.
  • Lipman CB (1912). Toxic effects of "Alkali Salts" in soils on soil bacteria. I. Ammonification. Centralbl. Bakt. 32: 5864.
  • Lipman CB and Wilson FH (1913). Toxic inorganic salts and acids as affecting plant growth. Bot. Gaz. 55: 409-420.
  • Marshall MS and Hrenoff AK (1937). Bacteriostasis. J. Infect. Dis. 61: 42-54.[Web of Science]
  • McCallan Sea and Wilcoxon F. (1931). The fungicidal action of sulphur. II. The production of hydrogen sulphide by sulphured leaves and spores and its toxicity to spores. Contrib. Boyce Thompson Inst. 3: 13-38.
  • Miller WS, Green CA, and Kitchen H. (1945). Biphasic action of penicillin and other similar sulphonamides. Nature 155: 210-211.[CrossRef][Web of Science]
  • Moore W. and Willaman JJ (1917). Studies in greenhouse fumigation with hydrocyanic acid: Physiological effects on the plant. J. Agric. Res. 11: 319-339.
  • Nageli C. (1893). Ueber oligodynamische Erscheinungen in labenden Zellen. Denkschr. Schweiz Naturforsch Ges. 33: 1-43.
  • Niethammer A. (1927). The stimulation effect of toxins on fungus and the Arndt-Schulz axion. Biochem. Z. 184: 370-382 (translated from the German by University of Massachusetts translation service).[Web of Science]
  • Noeldechen J. (1925). Uber die Reizwirkung von Metallsalzen auf die Keimung von Gerste. Kuehn-Arch. 9: 264-309.
  • Oberbaum M. and Cambar J. (1994). Hormesis: Dose-dependent reverse effects of low and very low doses. In: Ultra High Dilution, PC Endler and J Schultze (eds). Kluver Academic Publishers, Dordrecht, The Netherlands, pp. 5-18.
  • Ono N. (1900). Notes on the stimulating effect of certain substances upon the growth of algae and fungi. Bot. Mag. Tokyo 14: 75-78.
  • Popoff M and Gleisberg W (eds)(1924-1930). Zell-Stimulations-Forschungen, Vol 1-3, Paul Parey, Berlin.
  • Porter TM (1986). The Rise of Statistical Thinking, 1820-1900. Princeton University Press, Princeton.
  • Raulin J. (1869). Etudies chimiques sur la vegetation. Ann. Sci. Nat. Bot. V. 11: 93-299.
  • Reveil ( 1865). Recherches de physiologie vegetale. In: De l'action des poisons sur les plantes. Paris.
  • Richards HM (1897). Die Beeinflussung des Wachsthums einiger Pilze durch chemische Reinze. Jahrb. Fur Wiss. Bot. 30: 665-688.
  • Richards HM (1899). The effect of chemical irritation on the economic coefficient of sugar. Bull. Torrey Bot. Club 26: 463-479.[CrossRef]
  • Richards OW (1932). The stimulation of yeast growth by thallium, a "bios" impurity of asparagine. J. Biol. Chem. 96: 405-418.[Free Full Text]
  • Richards OW (1934). The effects of deuterium on the growth of yeast. J. Bacteriol. 28: 289-294.[Free Full Text]
  • Richards OW (1938). Colchicine stimulation of yeast growth fails to reveal mitosis. J. Bacteriol. 36: 187-195.[Free Full Text]
  • Richet C. (1905). De l'action de doses minuscules de substances sur la fermentation lactique. Arch. Intern. Physiol. 3: 203-217.
  • Richet C. (1906-1907). De 1' action de doses minuscules de substance sure le fermentation lacique-troisieme memoire—Periodes d'acceleration et ralentissement. Arch. Intern. Physiol. 4: 18-50.
  • Richter A. (1901). Zur Frage der chemischen Reizmittel. Centralbl. Bakt. 7: 417-429.
  • Rumm C. (1893). Ueber die Wirkung der Kapferpraparate bei Bekampfung der sogenannten Blattfallkrenkheit der Weinrebe. Bot. Z. 51: 163-164.
  • Salle AJ (1939). Fundamental Principles of Bacteriology. McGraw-Hill Book Co., Inc., New York.
  • Schreiner O. and Reed HS (1907). Some factors influencing soil fertility. Bullutin No. 40, U.S. Department of Agriculture, Bureau of Soil.
  • Schreiner O. and Reed HS (1908). The toxic action of certain organic plant constituents. Bot. Gaz. 45: 73-102; 271.
  • Schulz H. (1886). Die Wirkung der Thallinsalze auf Faulnis und Garung. Centralbl. Med. Wissensch. 24: 113-115.
  • Schulz H. (1887). Zur Lehre von der Arzneiwirdung. Virchows Arch. F. Pathol. U. Physiol. 108: 423-445.
  • Schulz H. (1888). Uber Hefegifte. Pfluegers Arch. Gesamte. Physiol. 42: 517-541.
  • Servos JW (1990). Physical Chemistry from Ostwald to Pauling. Princeton University Press, Princeton.
  • Sourkes T. (1966). Nobel Prize Winners in Medicine and Physiology. 1901-1905. Abeland-Schuman, New York.
  • Stebbing Ard (1982). Hormesis—The stimulation of growth by low levels of inhibitors. Sci. Total Environ. 22: 213-234.[CrossRef][Medline] [Order article via Infotrieve]
  • Stebbing Ard (1997). A theory for growth hormesis. BELLE Newsl. 6: 1-11.
  • Stevens FL (1898). The effect of aqueous solutions upon the germination of fungus spores. Bot. Gaz. 26: 377-406.
  • Stoklasa J. and Penkava J. (1928). Biologie des Uraniums. Biochem. Zeitschr. 194: 15-77.[Web of Science]
  • Storp F. (1883). Ueber den Einfluss von Kochsalz- und Zincsulfathaltigen Wassen auf Boden und Pflanzen. Landw. Jahrb. 12: 795-844.
  • Suzuki S. (1902-1903). On the action of highly diluted potassium iodide on agricultural plants. Bull. Coll. Agric. Jpn. 5: 199-201.
  • Suzuki S. (1902-1903). On the action of vanaiun compounds on plants. Bull. Coll. Agric. Jpn. 5: 513-515.
  • Suzuki S. (1902-1903). On the poisonous action of potassium ferrocyanid on plants. Bull. Coll. Agric. Jpn. 5: 203-205.
  • Suzuki S. and Aso K. (1902-1903). On the physiological action of iodine and fluorine compounds on agricultural plants. Part A: On the influence of iodide on oats. (S. Suzuki). Part B: On the influence of potassium iodide on radish. (S. Suzuki). Part C: On the influence of sodium fluoride on oats. (K. Aso). Bull. Coll. Agric. Jpn. 5: 473-479.
  • Thimann K. (1963). The Life of Bacteria, 2nd ed. Macmillan Co., New York.
  • Thol W. (1885). Ueber den Einfluss organischer, nichte aromatischer Sauren auf Gahrung und Faulnis. Greifswald, Inaugural Dissertation.
  • Townsend CO (1897). The correlation of growth under the influence of injuries. Ann. Bot. 11: 509-532.
  • Townsend CO (1899). The effect of ether upon the germination of seeds and spores. Bot. Gaz. 27: 458-466.
  • Townsend CO (1899). The effect of hydrocyanic acid gas upon the germination of seeds. Sci. Am. 48(suppl): 20010-20011.
  • Townsend CO (1901). The effect of hydrocyanic acid gas upon grains and other seeds. Bot. Gaz. 31: 241-264.
  • Townsend CO (1901). The effect of hydrocyanic acid gas upon grains and other seeds. Md. Agr. Exp. Sta. Bull. 75: 183-198.
  • True RH (1900). The toxic action of a series of acids and of their sodium salts on Lupinus albus. Am. J. Sci. IV 9: 183.
  • True RH and Gies WJ (1903). On the physiological action of some of the heavy metals in mixed solutions. Bull. Torrey Bot. Club 30: 390-402.[CrossRef]
  • True RH and Oglevee CS (1905). The effect of the presence of insoluble substances on the toxic action of poisons. Bot. Gaz. 39: 1-21.
  • Vichi P. and Tritton TR (1989). Stimulation of growth in human and murine cells by adriamycin. Cancer Res. 49: 2679-2682.[Abstract/Free Full Text]
  • Wassom JS (1989). Origins of genetic toxicology and the environmental mutagen society. Environ. Mol. Mutagen. 16(suppl): 1-6.
  • Watkins JH and Winslow C-EA (1932). Factors determining the rate of mortality of bacteria exposed to alkalinity and heat. J. Bacteriol. 24: 243-265.[Free Full Text]
  • Watterson A. (1904). The effect of chemical irritation on the respiration of fungi. Bull. Torrey Bot. Club 31: 291-303.[CrossRef]
  • Winslow C-EA and Dolloff AF (1928). Relative importance of additive and antagonistic effects of cations upon bacterial viability. J. Bacteriol. 15: 67-92.[Free Full Text]
  • Winslow C-EA and Haywood ET (1931). The specific potency of certain cations with reference to their effect on bacterial viability. J. Bacteriol. 22: 49-69.[Free Full Text]
  • Winslow C-EA and Hotchkiss M. (1922). Studies on salt action. V. The influence of various salts upon bacteria growth. Proc. Soc. Exper. Biol. Med. 19: 314-315.[CrossRef]

Toxicologic Pathology, Vol. 27, No. 2, 195-216 (1999)
DOI: 10.1177/019262339902700207
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